白藜芦醇（Res）以其在治疗多种癌症方面的潜力而闻名，其特点是引起最小的有毒副作用。然而，其临床应用受到了挑战的限制，如生物利用度差、溶解度低以及在中性和碱性环境中的化学不稳定性。鉴于这些限制，我们开发了一种pH响应性的药物输送纳米平台，Res@ZIF-8/TA NPs，在体外癌症治疗方面表现出良好的生物相容性和潜力。凭借沃纳尔酸–咪唑酮骨架（ZIFs）提供的温和反应条件，采用“一锅法”合成和负载药物，获得了令人满意的负载能力。值得注意的是，Res@ZIF-8/TA NPs能够对酸性环境做出反应，导致药物释放特性得到改善，并具有可控释放效应。我们的细胞实验表明，单宁酸（TA）修饰增强了ZIFs的生物相容性。MTT试验、Hoechst 33342/PI染色、细胞刮痕实验、Transwell和RT-qPCR（反向转录定量PCR）试验进一步证明了Res@ZIF-8/TA NPs抑制结肠癌细胞迁移和侵袭，并促进结肠癌细胞凋亡，表明其具有治疗潜力和抗癌性能。总之，我们开发的Res@ZIF-8/TA NPs pH响应性药物传递系统可能为癌症治疗提供了一个有前景的途径。通过解决与基于Res的治疗相关的一些挑战，此系统可能有助于癌症治疗的进展。© 2023 Wiley Periodicals LLC.

Resveratrol (Res) is known for its potential in treating various types of cancers, with a particular advantage of causing minimal toxic side effects. However, its clinical application is constrained by challenges such as poor bioavailability, low water solubility, and chemical instability in neutral and alkaline environments. In light of these limitations, we have developed a pH-responsive drug delivery nanoplatform, Res@ZIF-8/TA NPs, which exhibits good biocompatibility and shows promise for in vitro cancer therapy. Benefiting from the mild reaction conditions provided by zeolitic imidazolate frameworks (ZIFs), a "one-pot method" was used for drug synthesis and loading, resulting in a satisfactory loading capacity. Notably, Res@ZIF-8/TA NPs respond to acidic environments, leading to an improved drug release profile with a controlled release effect. Our cell-based experiments indicated that tannic acid (TA) modification enhances the biocompatibility of ZIFs. 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT assay), Hoechst 33342/PI staining, cell scratch assay, Transwell and Reverse Transcription quantitative PCR (RT-qPCR) assays further demonstrated that Res@ZIF-8/TA NPs inhibited colon cancer cell migration and invasion, and promoted apoptosis of colon cancer cells, suggesting a therapeutic potential and demonstrating anti-cancer properties. In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy. By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.© 2023 Wiley Periodicals LLC.