用68Ga-FAPI-46相对于18F-FDG PET/CT在一例SMARCA4缺陷未分化胃癌的转移病灶的优越性鉴定
Superior Identification of Metastatic Lesions by 68Ga-FAPI-46 to 18F-FDG PET/CT in a Case of SMARCA4-Deficient Undifferentiated Carcinoma of Stomach.
发表日期：2023 Sep 13
作者：
Yizhen Pang, Jiayu Cai, Liang Zhao, Weizhi Xu, Haojun Chen
来源：
CLINICAL NUCLEAR MEDICINE
摘要：
SMARCA4缺乏不分化癌是一种以SMARCA4失活为特征的新的临床实体，由于快速生长，其预后不佳。在此例中，我们报道了一例胃SMARCA4缺乏不分化癌患者的18F-FDG和68Ga-FAPI-46 PET/CT成像结果。68Ga-FAPI-46 PET/CT显示原发肿瘤与背景之间的对比度更高，并揭示出比18F-FDG PET/CT更多的转移病灶。该案例显示了68Ga-FAPI PET/CT在鉴定SMARCA4缺乏不分化癌的原发病灶和转移病灶方面的优势。这一观察结果可能为FAPI PET在肿瘤学成像中的益处提供了信息。版权所有: Copyright © 2023 Wolters Kluwer Health，Inc. All rights reserved.
SMARCA4-deficient undifferentiated carcinoma is a new clinical entity characterized by SMARCA4 inactivation and has a dismal prognosis because of rapid growth. In this case, we reported 18F-FDG and 68Ga-FAPI-46 PET/CT imaging findings in a patient with SMARCA4-deficient undifferentiated carcinoma of stomach. 68Ga-FAPI-46 PET/CT showed much higher tumor-to-background contrast of primary tumor and revealed more metastatic lesions than 18F-FDG PET/CT. This case demonstrated the superiority of 68Ga-FAPI PET/CT over 18F-FDG for identifying both primary and metastatic lesions in SMARCA4-deficient undifferentiated carcinoma. This observation may add the information on the benefit of FAPI PET in oncology imaging.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.