在过去的二十年里，迅速扩展的肿瘤代谢领域提高了我们对营养供给对癌症代谢重编程的影响的认识。除了在癌细胞本身中具有已知角色外，各种养分、代谢酶和应激反应对支持恶性转化的肿瘤微环境免疫、成纤维、内皮和其他细胞类型的活动至关重要。在本文中，我们回顾了营养供给如何影响癌症和“基质”细胞的代谢途径和响应的当前认识，通过剖析重要示例及其调控细胞活动。了解营养供给与肿瘤生态系统中细胞行为之间的关系将扩大在癌症中开发新型治疗易感性的视野。版权所有©2023 Elsevier Ltd. 保留所有权利。

Over the last two decades, the rapidly expanding field of tumor metabolism has enhanced our knowledge of the impact of nutrient availability on metabolic reprogramming in cancer. Apart from established roles in cancer cells themselves, various nutrients, metabolic enzymes, and stress responses are key to the activities of tumor microenvironmental immune, fibroblastic, endothelial, and other cell types that support malignant transformation. In this article, we review our current understanding of how nutrient availability affects metabolic pathways and responses in both cancer and "stromal" cells, by dissecting major examples and their regulation of cellular activity. Understanding the relationship of nutrient availability to cellular behaviors in the tumor ecosystem will broaden the horizon of exploiting novel therapeutic vulnerabilities in cancer.Copyright © 2023 Elsevier Ltd. All rights reserved.