日本血吸虫病可以引起不同程度的器官损伤和复杂的人体免疫病理反应，常侵犯肠道和肝脏。本研究旨在探讨日本血吸虫病的病理类型和病理变化，并与某些消化系统肿瘤进行相关性分析。我们对1111例日本血吸虫病患者的病变组织进行了苏木精-伊红染色。我们计数了血吸虫卵的沉积部位，分析了病理特征，并比较了与日本血吸虫病相关的消化系统肿瘤和非日本血吸虫病消化系统肿瘤的临床病理特征。我们发现日本血吸虫可以引起多器官和多系统的损伤，其中有469例炎症、47例腺瘤和519例腺癌。其他类型包括囊肿、间质性肿瘤、恶性淋巴瘤和神经内分泌肿瘤。与非日本血吸虫病相关的肿瘤，如胃癌、肝癌、结肠癌和直肠癌进行了比较。两组之间的年龄、性别和肿瘤分化度存在显著差异。我们的研究表明，日本血吸虫病是一种系统性疾病，会在人体内引起多个器官和系统的损害。其临床病理类型多样，可能存在一种“炎症-腺瘤-癌”的病理变化过程。与非日本血吸虫病肿瘤相比，与日本血吸虫病相关的消化系统肿瘤在某些临床病理特征上存在差异。© 2023. Springer Nature Limited.

Schistosomiasis japonicum can cause different degrees of organ damage and complex human immune pathological reactions, which often invade the intestine and liver. The purpose of this study was to explore the pathological types and pathological changes of Schistosomiasis and their correlation with some digestive system tumors. Hematoxylin eosin staining was performed on the diseased tissues of 1111 Schistosomiasis cases. We counted the deposition sites of Schistosoma eggs, analyzed the pathological characteristics, and compared the clinicopathological characteristics of Schistosomiasis associated digestive system tumors and non-Schistosomiasis digestive system tumors. We found that Schistosoma japonicum can cause multi organ and multi system damage, with 469 cases of inflammation, 47 cases of adenoma, and 519 cases of adenocarcinoma. Other types include cysts, stromal tumors, malignant lymphomas, and neuroendocrine tumors. Schistosomiasis associated tumors, including gastric cancer, liver cancer, colon cancer and rectal cancer, were compared with non-Schistosomiasis tumors. There were significant differences in age, gender and tumor differentiation between the two groups. Our study shows Schistosomiasis is a systemic disease, causing multiple organ and system damage in the human body. Its clinicopathological types are diverse, and there may be a pathological change process of "Inflammation-adenoma-carcinoma". Schistosomiasis associated digestive system tumors differ from non-Schistosomiasis tumors in some clinicopathological features.© 2023. Springer Nature Limited.