癌症是一种复杂的疾病，有许多因素都在其中起作用，研究人员已经获得了广泛的知识，帮助他们理解癌症的多样性和多变性。发现在众多癌症类型中发现的DNA甲基化模式的改变说明它们可能在疾病的进展中发挥作用。人类癌症条件涉及到DNA甲基转移酶3β（DNMT3B）基因的失调，这是一个重要的新陈代谢DNA甲基转移酶，其异常行为是肿瘤预后和分期的指标。非编码RNA（ncRNAs）的表达在控制靶基因表达和蛋白翻译方面起着重要的作用，其中包括微小RNA（miRNA）、长非编码RNA（lncRNAs）和环状RNA（circRNAs），它们的失调与肿瘤发生的相关性。ncRNAs的失调是影响癌细胞多种特征调控的关键因素，这些特征包括但不限于对药物的反应性、血管生成、转移、凋亡、增殖和肿瘤干细胞的特性。ncRNAs和DNMT3B的相互调控可以协同作用，影响肿瘤细胞的命运。因此，推进癌症预防和治疗的关键途径是研究DNMT3B和ncRNAs之间的相互作用。在本综述中，我们对ncRNAs/DNMT3B轴在癌症发病机制中全面概述，为癌症发生的复杂机制提供了有价值的洞见，为有效的治疗干预提供了基础。© 2023. BioMed Central Ltd., part of Springer Nature.

Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the diverse and varied nature of cancer. The altered patterns of DNA methylation found in numerous types of cancer imply that they may play a part in the disease's progression. The human cancer condition involves dysregulation of the DNA methyltransferase 3 beta (DNMT3B) gene, a prominent de novo DNA methyltransferase, and its abnormal behavior serves as an indicator for tumor prognosis and staging. The expression of non-coding RNAs (ncRNAs), which include microRNAs (miRNA), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), is critical in controlling targeted gene expression and protein translation and their dysregulation correlates with the onset of tumors. NcRNAs dysregulation of is a critical factor that influences the modulation of several cellular characteristics in cancerous cells. These characteristics include but are not limited to, drug responsiveness, angiogenesis, metastasis, apoptosis, proliferation, and properties of tumor stem cell. The reciprocal regulation of ncRNAs and DNMT3B can act in synergy to influence the destiny of tumor cells. Thus, a critical avenue for advancing cancer prevention and treatment is an inquiry into the interplay between DNMT3B and ncRNAs. In this review, we present a comprehensive overview of the ncRNAs/DNMT3B axis in cancer pathogenesis. This brings about valuable insights into the intricate mechanisms of tumorigenesis and provides a foundation for developing effective therapeutic interventions.© 2023. BioMed Central Ltd., part of Springer Nature.