T淋巴细胞（T细胞）是我们免疫系统中的重要细胞亚群，负责细胞介导的适应性免疫应答和免疫稳态的维持。T细胞功能异常导致感染持续存在、免疫监视能力下降、癌症生长无法抑制以及自身免疫疾病的发生。离子通道在调节T细胞信号传导和细胞功能中发挥关键作用，但通常被忽视和研究不足。目前对免疫细胞中离子通道的"通道组"（channelome）及离子通道之间的相互作用了解甚少。本综述旨在总结关于离子通道对T细胞功能和疾病的影响的发表数据。离子通道在健康和疾病中的重要性以及由于它们位于细胞质膜表面而易于接触，使其成为优秀的药物靶点。版权所有©2023 Manolios, Papaemmanouil和Adams。

T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of cancer growth, and autoimmune diseases. Ion channels play a critical role in the regulation of T cell signaling and cellular function and are often overlooked and understudied. Little is known about the ion "channelome" and the interaction of ion channels in immune cells. This review aims to summarize the published data on the impact of ion channels on T cell function and disease. The importance of ion channels in health and disease plus the fact they are easily accessible by virtue of being expressed on the surface of plasma membranes makes them excellent drug targets.Copyright © 2023 Manolios, Papaemmanouil and Adams.