合成、表征并研究了一种由顺-二氨合氨基甲酸根的铂(II)络合物[Pt(NH3)2(pacac)](NO3) (1, DPP-Pt)和一种由顺-二氨合唑菁-基葡萄糖酮-1,3-二苯丙酮酸根的铂(II)络合物[Pt(NH3)2(Acac-RB)](NO3) (2, Acacplatin-RB)。其中Hpacac为1,3-二苯基-1,3-丙酮酸根，HAcac-RB为红光活性双撒-丙烯基-BODIPY-附加醋酰甲酮。利用RB缩写代表红光BODIPY。在1:1的DMSO-DPBS (达尔比科磷酸盐缓冲液)中，络合物2显示出一个强吸收带，波长为λ = 652 nm (ε = 7.6 × 104 M-1 cm-1)，以及λ = 601 nm (ε = 3.1 × 104 M-1 cm-1)。其发射谱包括一个宽波峰，约于~673 nm (λex = 630 nm)附近。HAcac-RB和2的荧光量子产率(FF)分别为0.19和0.07。通过二氯二羟荧光素醋酸二酯和1,3-二苯基异苯并噻吩的检测，络合物2表明产生了单线态氧 (FD: 0.36) 作为活性氧种类的光生物生成物。光照仅导致配体释放量的轻微增加，形成具有化学活性的顺式铂类似物。在A549肺癌细胞和MDA-MB-231多药耐药乳腺癌细胞中，该络合物在光照暴露下显示了约70-100倍的细胞毒性增强作用，半数抑制浓度 (IC50) 为0.9-1.8 μM。共聚焦成像显示其线粒体定位，络合物2表现出抗转移特性。β-微管蛋白和Annexin V-FITC/propidium iodide染色结果显示，络合物2能诱导光选择性微管破裂和细胞凋亡，分别。© 2023 Wiley-VCH GmbH.

Cisplatin-derived platinum(II) complexes [Pt(NH3)2(pacac)](NO3) (1, DPP-Pt) and [Pt(NH3)2(Acac-RB)](NO3) (2, Acacplatin-RB), where Hpacac is 1,3-diphenyl-1,3-propanedione and HAcac-RB is a red-light active distyryl-BODIPY-appended acetylacetone ligand, are prepared, characterized and their photodynamic therapy (PDT) activity studied (RB abbreviated for red-light BODIPY). Complex 2 displayed an intense absorption band at λ = 652 nm (ε = 7.6 × 104 M-1 cm-1) and 601 nm (ε = 3.1 × 104 M-1 cm-1 ) in 1:1 DMSO-DPBS  (Dulbecco's Phosphate Buffered Saline). Its emission profile includes a broad maximum at ~673 nm (λex = 630 nm). The fluorescence quantum yield (FF) of HAcac-RB and 2 are 0.19 and 0.07, respectively. Dichlorodihydrofluorescein diacetate and 1,3-diphenylisobenzofuran  assay of complex 2 indicated photogeneration of singlet oxygen (FD: 0.36) as reactive oxygen species (ROS). Light irradiation caused only minor extent of ligand release forming chemo-active cisplatin analogue. The complex showed ~70-100 fold enhancement in cytotoxicity on light exposure in A549 lung cancer cells and MDA-MB-231 multidrug resistant breast cancer cells, giving half maximal inhibitory concentration (IC50) of 0.9-1.8 μM. Confocal imaging showed its mitochondrial localization and complex 2 exhibited anti-metastasis properties. Immunostaining of β-tubulin and Annexin V-FITC/propidium iodide staining displayed complex 2 induced photo-selective microtubule rupture and cellular apoptosis, respectively.© 2023 Wiley-VCH GmbH.