膀胱癌（BC）是影响泌尿系统的一种复杂疾病，并受多种致癌因子的调控。病毒感染是其中之一，引起了膀胱癌广泛的关注。人类乳头瘤病毒（HPV）是最常见的性传播感染之一，尽管多个研究者已经探讨了HPV在膀胱癌中的作用，但目前尚无共识。此外，与HPV相关的病毒（如人类免疫缺陷病毒、单纯疱疹病毒、BK病毒和JC病毒）似乎负责膀胱癌的发生和进展。本研究系统地回顾了HPV相关病毒与膀胱癌之间的关系，以阐明这些病毒在膀胱癌的发生和进展中的作用。此外，本研究旨在更深入地了解HPV相关病毒的生物学，并评估治疗病毒诱导的膀胱癌的潜在策略。研究还着重于快速发展的溶瘤病毒，为膀胱癌治疗提供了一种可能的新选择。©2023 The Authors. Journal of Medical Virology由Wiley Periodicals LLC出版。

Bladder cancer (BC) is a complex disease affecting the urinary system and is regulated by several carcinogenic factors. Viral infection is one such factor that has attracted extensive attention in BC. Human papillomavirus (HPV) is the most common sexually transmitted infection, and although multiple researchers have explored the role of HPV in BC, a consensus has not yet been reached. In addition, HPV-associated viruses (e.g., human immunodeficiency virus, herpes simplex virus, BK virus, and JC virus) appear to be responsible for the occurrence and progression of BC. This study systematically reviews the relationship between HPV-associated viruses and BC to elucidate the role of these viruses in the onset and progression of BC. In addition, the study aims to provide a greater insight into the biology of HPV-associated viruses, and assess potential strategies for treating virus-induced BC. The study additionally focuses on the rapid development of oncolytic viruses that provide a potentially novel option for the treatment of BC.© 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.