原发性脑肿瘤是儿童中最常见的实体肿瘤，癫痫是常见的表现症状。手术干预改善了恶性肿瘤的结果和癫痫的负担。对于儿童原发性脑肿瘤手术治疗中影响癫痫结果的因素的更好了解可以指导治疗方法，从而改善患者的生活质量。我们使用从1990年1月至2022年8月在PubMed、EMBASE和Cochrane查询到的文章进行了系统分析，以确定儿童脑原发性肿瘤切除术后癫痫结果的预测因素。我们鉴定了24个回顾性队列研究、1个前瞻性队列研究和1个回顾性和前瞻性混合研究进行了系统分析。共有831名儿童患者可用于分析。手术后有668名（80.4％）患者实现了无癫痫发作。与亚全切除（OR 7.1，95％CI 2.3-21.9）相比，完全切除肿瘤增加了无癫痫发作的可能性。根据发作开始时年龄，癫痫持续时间，性别，肿瘤侧化和手术年龄等因素，Engel I癫痫结果的发生率没有显著差异，但在颞叶肿瘤方面趋向性显著改善。儿童人群中的原发性脑肿瘤常与癫痫相关。切除这些病变可以减轻癫痫负担，并与高癫痫自由率相关。与亚全切除相比，完全切除显著提高了癫痫自由结果的可能性。© 2023年。作者，独家许可给Springer Science+Business Media，LLC，Springer Nature的一部分。

Primary brain neoplasms are the most common solid tumors in pediatric patients and seizures are a common presenting symptom. Surgical intervention improves oncologic outcomes and seizure burden. A better understanding of factors that influence seizure outcomes in the surgical management of primary brain tumors of childhood can guide treatment approach thereby improving patient quality of life.We performed a systematic analysis using articles queried from PubMed, EMBASE, and Cochrane published from January 1990 to August 2022 to determine predictors of seizure outcomes in pediatric patients undergoing resection of primary brain tumors.We identified 24 retrospective cohort studies, one prospective cohort study, and one mixed retrospective and prospective study for the systematic analysis. A total of 831 pediatric patients were available for analysis. 668 (80.4%) patients achieved seizure freedom after surgery. Complete tumor resection increased the likelihood of a seizure-free (Engel I) outcome compared to subtotal resection (OR 7.1, 95% CI 2.3-21.9). Rates of Engel I seizure outcomes did not significantly differ based on factors such as age at seizure onset, duration of epilepsy, gender, tumor laterality, or age at surgery, but trended towards significance for improved outcomes in temporal lobe tumors.Primary brain tumors in the pediatric population are commonly associated with seizures. Resection of these lesions reduces seizure burden and is associated with high rates of seizure freedom. Complete resection, compared to subtotal resection, significantly increases the likelihood of seizure-free outcomes.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.