血管免疫母细胞性T细胞淋巴瘤-表现为全身性红斑狼疮病例报告及文献综述。
Angioimmunoblastic T-cell Lymphoma Mimicking Systemic Lupus Erythematosus: A Case Report and Literature Review.
发表日期:2023 Sep 15
作者:
Yanni Wang, Zhenglun Pan
来源:
Immunity & Ageing
摘要:
本研究旨在调查模拟系统性红斑狼疮(SLE)的血管免疫增生性T细胞淋巴瘤(AITL)的临床特征,并提高风湿病学家对AITL的认识,以避免误诊和漏诊。本研究报道了一例表现为SLE的AITL,并进行了文献回顾。使用关键词搜索了Pubmed数据库中2022年5月之前发表的相关文章,并收集和分析了其中的临床特征。文献回顾共检索到6篇病例报告,其中四例最初被诊断为SLE,后来诊断为AITL。另外两例分别被诊断为SLE和AITL。这两种疾病在发病机制上存在关联并共有一些共同特征。AITL的临床表现复杂,与免疫功能异常密切相关,且异质性很高。AITL患者通常预后不良。报道的病例中很少出现AITL模拟SLE的情况。在临床实践中应考虑到AITL,以防止漏诊或误诊。
This study aimed to investigate the clinical features of angioimmunoblastic T-cell lymphoma (AITL) mimicking systemic lupus erythematosus (SLE) and raise awareness about AITL among rheumatologists in order to prevent misdiagnosis and missed diagnosis. The study reports on a case of AITL mimicking SLE and provides a literature review.Using key words as search terms, relevant articles published in PubMed before 2022-05 were searched, and their clinical characteristics were collected and analyzed.The literature review retrieved six case reports, including four cases initially diagnosed with SLE and then with AITL. The other two case diagnoses were SLE and AITL, respectively. The two diseases are pathogenically associated and share some common features. The clinical manifestations of AITL are complex. The disease is closely associated with abnormal immune functions and is highly heterogeneous.Patients with AITL generally have a poor prognosis. Rarely do reported cases show AITL mimicking SLE. AITL should be considered during clinical practice to prevent missed diagnoses or misdiagnoses.