从视网膜母细胞瘤患者结膜中诱导并鉴定出两株诱导多能干细胞系。
Generation and characterization of two induced pluripotent stem cell lines from conjunctiva of a retinoblastoma patient.
发表日期：2023 Sep 09
作者：
Ping Xu, Fuying Guo, Wei Xiao, Yuan Wang, Ke Ye, Yuxiang Mao, Xiufeng Zhong
来源：
Stem Cell Research & Therapy
摘要：
视网膜母细胞瘤（RB）是一种常见的眼内恶性肿瘤，主要由肿瘤抑制基因RB1的变异引起。在本研究中，我们成功地从一名非可遗传RB患儿中培养出两株诱导多能干细胞（iPSC）系。这两个细胞克隆表现出典型的iPSC特性，核型正常，表达一致的多能性标记物，并具有三系分化的能力。版权所有 © 2023 Elsevier B.V. 发表。
Retinoblastoma (RB) is a common intraocular malignancy mostly caused by variation of the tumour suppressor gene RB1. In this study, we successfully generated two induced pluripotent stem cell (iPSC) lines from an infant with non-heritable RB. Both cell clones exhibited typical iPSC characteristics with normal karyotypes, consistent pluripotency markers expression and the capability of trilineage differentiation.Copyright © 2023. Published by Elsevier B.V.