乳腺癌的特点是酸性微环境。酸性细胞外pH使癌细胞具有进化优势，因此，中和细胞外pH已被认为是一种潜在的治疗策略。为了解决全身pH改变的问题，已经研究了一种基于定向输送缓冲溶液到肿瘤区域的方法。该方法依赖于低频超声和装载碱性pH缓冲溶液的声敏脂质体（LipHUS）。在静脉注射LipHUS后，施加超声（US）在病变部位引起局部pH增加，结果高度有效地i）抑制原发性肿瘤生长，ii）降低手术后肿瘤复发率，和iii）抑制转移形成。实验是在三阴性乳腺癌小鼠模型中进行的。所得结果表明，声敏脂质体中碳酸氢盐或PBS缓冲液的局部和触发释放代表了治疗三阴性乳腺癌的有效工具。这种方法在潜在的临床转化方面具有潜力。本文受版权保护。保留所有权利。

Breast cancer is characterized by an acidic micro-environment. Acidic extracellular pH give cancer cells an evolutionary advantage, hence, neutralization of the extracellular pH has been considered as a potential therapeutic strategy. To address the issue of systemic pH alteration, an approach based on the targeted delivery of the buffering solution to the tumour region has been investigated. The method relies on the use of low frequency ultrasound and sono-sensitive liposomes loaded with buffers at alkaline pH (LipHUS). After the i.v. injection of LipHUS, the application of ultrasound (US) at the sites of the pathology induce a local increase of pH that resulted highly effective in i) inhibiting primary tumor growth, ii) reducing tumor recurrence after surgery, and iii) suppressing metastases' formation. The experiments were carried out on a triple negative breast cancer mouse model. The results obtained demonstrate that localized and triggered release of bicarbonate or PBS buffer from sonosensitive liposomes represents an efficient therapeutic tool for treating triple-negative breast cancer. This approach holds promise for potential clinical translation. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.