诺异吡啶在治疗人类疾病的医药领域具有的治疗重要性和药理活性。
Therapeutic Importance and Pharmacological Activities of Norisoboldine in Medicine for the Treatment of Human Disorders.
发表日期:2023 Sep 14
作者:
Dinesh Kumar Patel, Kanika Patel
来源:
Arthritis & Rheumatology
摘要:
天然产品是一类独特的化学化合物源,具有广泛的针对复杂人类疾病治疗的多靶点潜力。植物化学物质是植物的纯粹成分,主要负责其治疗潜力和药理活性。来自药用植物的天然产物已被用作药物的引导来源。正异博旻是一种重要的异喹啉类生物碱,被发现存在于南五味子干燥根中。本文从Google、Google Scholar、PubMed、Science Direct和Scopus收集了正异博旻的科学数据,并分析了其在医学中的生物潜力和治疗效果。本研究收集和分析了正异博旻的药用重要性和治疗潜力的科学数据。此外,所有收集的科学数据都被分成了不同的子部分,即药用重要性、药理活性和分析方面。本研究详细分析了正异博旻的药理活性数据,以了解其在医学中的治疗效果。本研究还收集和分析了正异博旻的分析数据。科学数据分析揭示了异喹啉类生物碱在药学中的生物重要性。异喹啉类生物碱是纯净、活性的植物化学物质,存在于多种天然食品中,包括蔬菜、植物和水果。正异博旻对关节炎、结肠炎、细胞凋亡、破骨细胞分化、炎症性疼痛、肾脏缺血再灌注损伤、急性肺损伤、促炎细胞因子、肿瘤、调节性T细胞和内皮细胞迁移具有生物学效应。然而,为了获得更好的治疗效果,也制备了正异博旻的纳米乳化药物输送系统。本研究还讨论了正异博旻的分析参数,以获取有关正异博旻的分离、提取和鉴定参数的科学信息。本研究揭示了正异博旻在医学中的治疗潜力。版权所有© Bentham Science Publishers;如有任何问题,请发送电子邮件至epub@benthamscience.net。
Natural products constitute a unique source of chemical compounds with vast multi-target potential for the treatment of complex human disorders. Phytochemicals are pure phytoconstituents of plants, mainly responsible for their therapeutic potential and pharmacological activities. Natural products isolated from medicinal plants have been used as a lead source of drug. Norisoboldine is an important isoquinoline alkaloid found to be present in the dry root of Lindera aggregate.In the present paper, scientific data of norisoboldine have been collected from Google, Google Scholar, PubMed, Science Direct and Scopus and analyzed in order to know the biological potential and therapeutic effectiveness of norisoboldine in medicine. Scientific data of medicinal importance and therapeutic potential of norisoboldine has been collected and analyzed in the present work. Moreover, all the collected scientific data have been separated into different sub-section i.e. Medicinal importance, pharmacological activities and analytical aspects. Detailed pharmacological activity data of norisoboldine have been analyzed in the present work to know the therapeutic effectiveness of norisoboldine in medicine. Analytical data of norisoboldine have also been collected and analyzed in the present work.Scientific data analysis revealed the biological importance of isoquinoline alkaloids in medicine. Isoquinoline alkaloids are pure, active phytochemical present in several natural edible products including vegetables, plants, and fruits. Norisoboldine has a biological effect on arthritis, colitis, apoptosis, osteoclast differentiation, inflammatory pain, renal ischemia-reperfusion injury, acute lung injury, pro-inflammatory cytokines, tumor, regulatory T cells, and endothelial cell migration. However nanoemulsifying drug delivery system of norisoboldine has also been prepared in order to get better therapeutic value. Further analytical parameters of norisoboldine were also discussed in the present work in order to get the scientific information of separation, isolation and identification parameter of norisoboldine.Present work revealed the therapeutic potential of norisoboldine in medicine.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.