维生素A长期以来与膀胱癌有关联，多年来已研究了许多外源性维生素A补充剂、维生素A衍生物和合成药物。然而，这些策略在临床实践中的有效性并未达到预期，并未被广泛采用。最近的医学研究显示，肠道菌群与膀胱癌患者的血清维生素A水平下降及肠道菌群失衡有关。考虑到肠道菌群和维生素A之间的密切关系，可以推测在膀胱癌的发展和发生过程中存在着复杂的调控机制。因此，进一步探究它们在膀胱癌中的相互作用可能有助于指导维生素A的预防应用。在本综述的过程中，重点关注肠道菌群对维生素A代谢和RA信号通路的影响，以及它们在膀胱癌预防中的相互促进关系。此外，强调了肠道菌群对膀胱癌预防和治疗的重要性。版权所有 © 2023 罗、郑、邹、陈、邹、李、陈和钱。

Vitamin A has long been associated with bladder cancer, and many exogenous vitamin A supplements, vitamin A derivatives, and synthetic drugs have been investigated over the years. However, the effectiveness of these strategies in clinical practice has not met expectations, and they have not been widely adopted. Recent medical research on intestinal flora has revealed that bladder cancer patients exhibit reduced serum vitamin A levels and an imbalance of gut microbiota. In light of the close relationship between gut microbiota and vitamin A, one can speculate that a complex regulatory mechanism exists between the two in the development and occurrence of bladder cancer. As such, further exploration of their interaction in bladder cancer may help guide the use of vitamin A for preventive purposes. During the course of this review, attention is paid to the influence of intestinal microbiota on the vitamin A metabolism and the RA signaling pathway, as well as the mutual promotion relationships between them in the prevention of bladder cancer, In addition, it emphasizes the importance of intestinal microbiota for bladder cancer prevention and treatment.Copyright © 2023 Luo, Zheng, Zou, Chen, Zou, Li, Chen and Qian.