雌激素受体α（ERα）是一种类固醇受体，在大多数乳腺癌的发生和进展中起关键作用。ERα通过招募关键的共调节因子调控基因转录，其中包括类固醇受体共激活因子AIB1（Amplified in Breast Cancer 1）。AIB1本身是一个致癌基因，在一些乳腺癌中过度表达，并通过多种机制参与肿瘤进展和内分泌治疗抵抗。在本文中，我们综述了AIB1在ERα依赖和ERα非依赖作用中的正常和病理功能，以及其基因组保守性和蛋白质进化。我们还概述了以AIB1为靶点治疗乳腺癌的努力。版权所有 © 2023 Kiliti, Sharif, Martin, Wellstein and Riegel.

The estrogen receptor alpha (ERα) is a steroid receptor that is pivotal in the initiation and progression of most breast cancers. ERα regulates gene transcription through recruitment of essential coregulators, including the steroid receptor coactivator AIB1 (Amplified in Breast Cancer 1). AIB1 itself is an oncogene that is overexpressed in a subset of breast cancers and is known to play a role in tumor progression and resistance to endocrine therapy through multiple mechanisms. Here we review the normal and pathological functions of AIB1 in regard to its ERα-dependent and ERα-independent actions, as well as its genomic conservation and protein evolution. We also outline the efforts to target AIB1 in the treatment of breast cancer.Copyright © 2023 Kiliti, Sharif, Martin, Wellstein and Riegel.