青少年和感染风险增加、相关后果的人群接种人乳头瘤病毒（HPV）疫苗是预防生殖器癌症的有效策略。本研究的目的是评估意大利东北地区的疫苗接种活动和覆盖率。通过匿名随机秘钥，将意大利人口为53万的健康机构“Azienda Sanitaria Universitaria Friuli Centrale”各种卫生行政数据库的匿名数据在个体级别上进行确定性链接。计算了每年接种的HPV疫苗剂量和不同出生队列的覆盖率。还确定了接受CIN2+病变治疗的女性的接种情况。每年接种的疫苗剂量的数量遵循了国家和地区法律的演变。2020年和2021年在男性和女性中均观察到了急剧下降（2019年男性为6907剂，2020年下降到5027剂；2019年女性为6989剂，2020年下降到4348剂）。不同亚区疫苗接种服务的青少年覆盖率存在差异（2008年队列的完整接种循环在某些地区为<40%，在其他地区为>70%）。成年女性接种的疫苗剂量自2018年以来几乎持续增加。接受CIN2+病变治疗的女性中有三分之一接种过疫苗。在该区域，应努力在疫情期间错过的剂量上追赶，并克服不同亚区之间的差异。

Vaccination against human papilloma virus (HPV) in adolescents and persons at increased risk of infection and related consequences is an effective strategy to prevent genital cancers. The objective of this study was to assess vaccination activity and coverages in a Northeastern Italian area.Anonymous data from various health administrative databases of the Italian 530,000-inhabitant Health Authority "Azienda Sanitaria Universitaria Friuli Centrale" were deterministically linked at the individual level through an anonymous stochastic key. Doses of HPV vaccine administered by year and coverages in different birth cohorts were calculated. Vaccinations of women treated for a CIN2+ lesion were also identified.The number of doses administered by year followed the evolution of national and regional laws. A steep drop was observed in 2020 and 2021 in both males and females (from 6,907 in 2019 to 5,027 in 2020 in males and from 6,989 in 2019 to 4,348 in 2020 in females). Coverages in adolescents were variable across Vaccination Services located in different sub-areas (complete cycle coverage in the 2008 cohort ranged from <40% in some Districts to >70% in others). Vaccination doses administered in adult women have increased almost steadily since 2018. One third of women treated for a CIN2+ were vaccinated.In this area, efforts must be done to catch-up with doses missed during the pandemic and to overcome differences among different sub-areas.