铁死亡（ferroptosis）是一种新型的调控性细胞死亡（RCD），其特点是铁离子失衡和无限制的脂质过氧化。新兴的证据表明，铁死亡在某些病理过程中发挥了关键作用，尤其是在癌症中。触发铁死亡可以抑制肿瘤生长并诱导抗肿瘤免疫反应，显示出针对铁死亡治疗癌症的疗效前景。作为一种自噬现象，铁蛋白噬菌体（ferritinophagy）通过降解铁蛋白以释放细胞内游离铁来诱导铁死亡。近年来，人们在设计和开发基于靶向铁蛋白噬菌体诱导铁死亡的抗癌策略方面付出了大量努力。本综述首先阐述了铁蛋白噬菌体的调控机制，并总结了铁蛋白噬菌体诱导的铁死亡在癌症中的作用。此外，重点介绍了靶向铁蛋白噬菌体诱导铁死亡的策略，以揭示铁蛋白噬菌体作为治疗癌症靶点的治疗价值。最后，对如何应对开发铁蛋白噬菌体促进剂成为临床治疗药物面临的挑战的未来研究方向进行了讨论。© 2023.Springer Nature Switzerland AG.

Ferroptosis, a newly form of regulated cell death (RCD), is characterized by iron dyshomeostasis and unrestricted lipid peroxidation. Emerging evidence depicts a pivotal role for ferroptosis in driving some pathological processes, especially in cancer. Triggering ferroptosis can suppress tumor growth and induce an anti-tumor immune response, denoting the therapeutic promises for targeting ferroptosis in the management of cancer. As an autophagic phenomenon, ferritinophagy is critical to induce ferroptosis by degradation of ferritin to release intracellular free iron. Recently, a great deal of effort has gone into designing and developing anti-cancer strategies based on targeting ferritinophagy to induce ferroptosis.This review delineates the regulatory mechanism of ferritinophagy firstly and summarizes the role of ferritinophagy-induced ferroptosis in cancer. Moreover, the strategies targeting ferritinophagy to induce ferroptosis are highlighted to unveil the therapeutic value of ferritinophagy as a target to manage cancer. Finally, the future research directions on how to cope with the challenges in developing ferritinophagy promoters into clinical therapeutics are discussed.© 2023. Springer Nature Switzerland AG.