尽管炎症是一种重要的免疫应答，有助于保护机体免受感染，但过度或持续的炎症可能导致多种令人痛苦的疾病，包括皮肤病、糖尿病、心脏病、中风、自身免疫病和癌症。炎症是一种分级响应，通常在当地巨噬细胞察觉到组织中存在病原体或损伤时被启动，巨噬细胞会产生炎症细胞因子和趋化因子，以杀死病原体、清除碎片和坏死组织，并启动组织修复。本研究表明，铜纳米材料可以通过阻断巨噬细胞在暴露于细菌细胞壁成分LPS后产生炎症细胞因子，从而预防炎症。机制上，我们证明铜纳米材料可以显著减少LPS刺激巨噬细胞中NF-κB 和 IRF3的激活。鉴于过度炎症在糖尿病中的重要性，我们展示了铜可以通过减少肌肉细胞中的炎症细胞因子介导的胰岛素抵抗来改善胰岛素敏感性。我们的数据显示，铜纳米材料可能有助于减少巨噬细胞中的过度炎症并改善骨骼肌的胰岛素敏感性。 版权声明：© 2023 Zangiabadi等。本文为开放获取文章，根据知识共享署名许可协议，任何人可以自由使用、发布和再现本文，但必须注明原始作者和出处。

While inflammation is an important immune response for protection from infections, excessive or prolonged inflammation can lead to a variety of debilitating diseases including skin disease, diabetes, heart disease, stroke, autoimmune diseases and cancer. Inflammation is a graded response that is typically initiated when resident macrophages sense the presence of pathogens or damage in the tissue and produce inflammatory cytokines and chemokines to kill the pathogen, clear debris and dead tissue, and initiate tissue repair. Here we show that copper-infused fabrics can prevent inflammation by blocking the production of inflammatory cytokines from macrophages after being exposed to LPS, a component of bacterial cell wall. Mechanistically, we show that copper-infused fabrics can significantly reduce the NF-κB and IRF3 activation in LPS-stimulated macrophages. Given the importance of excessive inflammation in diabetes, we show that copper can reduce insulin resistance mediated by inflammatory cytokines in muscle cells. Our data show that copper infused fabrics may be useful to reduce excessive inflammation in macrophages and improve insulin sensitivity in skeletal muscles.Copyright: © 2023 Zangiabadi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.