最近，有几项研究探讨了与结直肠肿瘤相关的炎症生物标志物在人体内的浓度，并研究了系统性细胞因子谱和炎症标志物在结直肠癌中的预后价值。然而，关于结直肠腺瘤和早期癌症中的炎症生物标志物了解甚少。我们比较了112例腺瘤患者、72例结直肠癌Tis`T1分期患者、34例结直肠癌T2-T4分期患者和53名正常受试者血浆中38种炎症标志物的水平。总结起来，我们发现8种炎症生物标志物（Eotaxin、GCSF、IL-4、IL-5、IL-17E、MCP-1、TNF-alpha、VEGF-A）在结直肠腺瘤和癌症患者的血浆浓度较50岁以上正常参与者高，并可能具有结直肠腺瘤和早期癌症的预后价值。© 本文作者2023年。牛津大学出版社保留所有权利。如需权限，请发送电子邮件至：journals.permissions@oup.com。

Recently, several studies have explored inflammatory biomarkers associated with colorectal neoplasms in human plasma and investigated the prognostic value of systemic cytokine profiles and inflammatory markers in colorectal cancer. However, little is known about inflammatory biomarkers in colorectal adenoma and early cancer. We compared the level of 38 inflammatory markers in the plasma of 112 adenoma patients, 72 Tis`T1 staging of colorectal carcinoma patients, 34 T2-T4 staging of colorectal carcinoma patients and 53 normal subjects. In summary, we found that eight inflammatory biomarkers (Eotaxin, GCSF, IL-4, IL-5, IL-17E, MCP-1, TNF-alpha, VEGF-A) have higher plasma concentrations in colorectal adenoma and cancer patients compared to normal participants over 50 years old and may have the prognostic value for colorectal adenoma and early -stage carcinoma.© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.