三分结构域蛋白(TRIMs)家族代表了一类高度保守的蛋白质，它们在分子过程中扮演着重要的调控角色。最近的证据越来越多地证明了TRIMs在女性生殖系统肿瘤中的作用。因此，我们的综述旨在概述TRIMs在女性生殖系统肿瘤中的生物参与，以更好地理解其在这些疾病的发展和进展中的作用，并强调其作为靶向癌症治疗的潜力。总的来说，我们的综述突显了TRIMs的广泛作用，不仅包括靶向蛋白泛素化、肿瘤迁移和/或侵袭、上皮间质转变、干细胞特性、细胞黏附、增殖、细胞周期调控和凋亡，还包括对雌激素作用和化疗反应的影响。版权所有 © 2023。Elsevier GmbH出版。

The tripartite motif proteins (TRIMs) family represents a class of highly conservative proteins which play a large regulatory role in molecular processes. Recently, increasing evidence has demonstrated a role of TRIMs in female genital neoplasms. Our review thereby aimed to provide an overview of the biological involvement of TRIMs in female genital neoplasms, to provide a better understanding of its role in the development and progression of such diseases, and emphasize its potential as targeted cancer therapy. Overall, our review highlighted that the wide-ranging roles of TRIMs, in not only target protein ubiquitination, tumor migration and/or invasion, epithelial-mesenchymal transition, stemness, cell adhesion, proliferation, cell cycle regulation, and apoptosis, but also in influencing estrogenic, and chemotherapy response.Copyright © 2023. Published by Elsevier GmbH.