旋律大师：揭示miRNA在恶性胸膜间皮瘤的诊断、进展和药物耐药中的作用。
Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma.
发表日期：2023 Sep 13
作者：
Mai A Abd-Elmawla, Sherif S Abdel Mageed, Tohada M Al-Noshokaty, Mohammed S Elballal, Ahmed I Abulsoud, Shereen Saeid Elshaer, Ahmed A El-Husseiny, Doaa Fathi, Heba M Midan, Nehal I Rizk, Mahmoud A Elrebehy, Ghadir A Sayed, Manar Mohammed El Tabaa, Aya Salman, Osama A Mohammed, Alaa Ashraf, Emad Gamil Khidr, Reem Khaled, Walaa A El-Dakroury, Gouda Kamel Helal, Yasser M Moustafa, Ahmed S Doghish
来源：
Cellular & Molecular Immunology
摘要：
恶性胸膜间皮瘤（MPM）是一种严重导致患者预后不良的胸膜癌的形式，特点是有效治疗手段匮乏。此外，许多患者在晚期被诊断出来后经历了重大副作用。MPM的可用诊断、预后和治疗选项受到限制。微小RNA（miRNAs）是一类小型非编码RNA分子的子集，在细胞生物学中对多个细胞过程发挥重要的调控作用。多种miRNAs在癌症中表达异常，作为抑癌基因或癌基因的特定功能。本综述旨在概述、概括和分析最新的学术研究，研究认为miRNAs与MPM引起的失调相关。此外，还讨论了miRNAs作为MPM诊断和预后生物标志物的潜在临床用途。未来有望提高MPM的诊断、预后和治疗模式，miRNAs被看作是这些进展的潜在触发因素。版权所有©2023 Elsevier GmbH。保留所有权利。
Malignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable prognoses for afflicted individuals. Besides, many patients experience substantial consequences from being diagnosed in advanced stages. The available diagnostic, prognostic, and therapeutic options for MPM are restricted in scope. MicroRNAs (miRNAs) are a subset of small, noncoding RNA molecules that exert significant regulatory influence over several cellular processes within cell biology. A wide range of miRNAs have atypical expression patterns in cancer, serving specific functions as either tumor suppressors or oncomiRs. This review aims to collate, epitomize, and analyze the latest scholarly investigations on miRNAs that are believed to be implicated in the dysregulation leading to MPM. miRNAs are also discussed concerning their potential clinical usefulness as diagnostic and prognostic biomarkers for MPM. The future holds promising prospects for enhancing diagnostic, prognostic, and therapeutic modalities for MPM, with miRNAs emerging as a potential trigger for such advancements.Copyright © 2023 Elsevier GmbH. All rights reserved.