长链非编码RNA转移相关肺腺癌转录本1（MALAT1）可以调控多种癌症的肿瘤发生和进展。然而，在清除型肾细胞癌（ccRCC）中，关于MALAT1的肿瘤生物学和调控机制的了解很少。本研究的目的是基于癌症基因组图谱评估MALAT1在ccRCC中的预后价值和潜在功能。通过生物信息学研究，我们分析了ccRCC中MALAT1的表达，并与临床病理特征、总体生存率和免疫细胞浸润的关系进行了分析，并建立了预后模型。结果显示MALAT1在ccRCC组织中高度表达，并且预测了ccRCC患者的不良预后。MALAT1的表达水平与组织学分级、病理分级、T分期和M分期显著相关。ROC曲线显示MALAT1具有良好的诊断准确性，曲线下面积为0.752。单变量和多变量Cox回归分析显示高MALAT1表达是癌症基因组图谱中总体生存的独立预后因素（风险比=2.271，95%可信区间：1.435-3.593，P<0.001）。基因集富集分析显示MALAT1表达与DNA甲基化、基因表达表观遗传调控信号通路相关。此外，我们建立了预测1年、3年和5年生存的预后模型。本研究表明，MALAT1的高表达可能是一个潜在的诊断和预后生物标志物。《2023年版权所有作者。由Wolters Kluwer Health，Inc.出版。

Long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) can regulate tumorigenesis and progression of various cancers. However, there is little known about the tumor biology and regulatory mechanism of MALAT1 in clear cell renal cell carcinoma (ccRCC). The objective of this study was to evaluate the prognostic value and potential functions of MALAT1 in ccRCC based on the cancer genome atlas. Through bioinformatics research, we analyzed the expression of MALAT1 in ccRCC, and the relationship with clinicopathological features, overall survival and infiltration of immune cells, and established the prognostic models. The results showed that MALAT1 was highly expressed in ccRCC tissues and predicted poor ccRCC patient outcome. The expression level of MALAT1 was significantly correlated with histologic grade, pathologic grade, T stage, M stage. ROC curve showed that MALAT1 had a good diagnostic accuracy, area under the curve of 0.752. The univariate and multivariate cox regression analysis showed that high MALAT1 expression was an independent prognostic factor for overall survival in the cancer genome atlas (hazard ratio = 2.271, 95% confidence interval: 1.435-3.593, P < .001). Gene set enrichment analysis revealed that MALAT1 expression was associated with the DNA methylation, epigenetic regulation of gene expression signaling pathway. In addition, the prognostic models were established to predict 1-, 3- and 5-year survival. This study showed that high expression of MALAT1 might be a potential diagnostic and prognostic biomarker.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.