获取儿科肿瘤患者的尸检组织对研究至关重要，并有助于治愈哀伤的家庭。自2019年以来，全国儿童赠予计划在收集儿科中枢神经系统肿瘤患者的尸检组织方面取得了重要进展，以推进研究。在严重急性呼吸综合征冠状病毒2型疫情爆发期间，尸检计划停顿，这一进展陷入危险之中。我们对纪念斯隆·凯特琳肿瘤中心治疗并在魏尔·康奈尔医学院进行尸检的四名患者进行了回顾性审查，时间为2020年6月至2021年3月。我们收集了患者人口统计学资料，不复苏状态、死亡及手术时间、受2019年冠状病毒病（COVID-19）疫情限制的情况以及组织分析结果。四个样本中有三个在死亡后12小时内进行了处理。两个家庭需要翻译服务以获得同意。在所有情况下，肿瘤样本被快速冻结以供进一步研究。细胞系的建立在一个案例中取得了成功。所有家庭都表达了参与的机会以及程序处理方面的感激之情。尽管这些案例具有敏感性质，并且受到COVID-19限制的挑战，但临床医生应根据科学需求和对悲伤家庭的积极影响，向儿童患者的看护人提供快速尸检的选择。本文概述了这些捐赠所需的后勤工作，并为医务人员提供了通过这个计划为家庭提供快速尸检选择的框架。版权所有 ©2023年 Elsevier Inc.

Obtaining postmortem tissue from pediatric oncology patients is critical to research and may help grieving families heal. Since 2019, the national Gift from a Child program has made significant progress in collecting postmortem tissue from pediatric patients with central nervous system tumors to advance research. This progress was at risk during the onset of the severe acute respiratory syndrome coronavirus 2 pandemic, when some autopsy programs came to a halt.We retrospectively reviewed autopsies of four patients treated at Memorial Sloan Kettering Cancer Center who underwent postmortem examination at Weill Cornell Medicine from June 2020 to March 2021. We collected patient demographics, Do not resuscitate status, time of death and procedure, restrictions due to the coronavirus disease 2019 (COVID-19) pandemic, and results of the tissue analysis.Three of four specimens were processed within 12 hours of the time of death. Two families required interpreter services to obtain consent. In all cases, tumor aliquots were flash frozen for further study. Cell line generation was successful in one case. All families expressed gratitude both for the opportunity to participate and for the handling of the procedures.Despite the sensitive nature of these cases and the challenges presented by COVID-19 restrictions, clinicians should offer the option of a rapid autopsy to caregivers of pediatric patients based on the scientific need and the positive effect it has on grieving families. This article outlines the logistic efforts required for these donations to take place and provides a framework for providers to offer rapid autopsy as an option for families through this program.Copyright © 2023. Published by Elsevier Inc.