TGF-β调节系统在维持生物完整性方面起着关键作用。通过对多种细胞类型在共享生态系统中的细胞增殖、表型可塑性、迁移、代谢适应和免疫监视的协同影响，TGF-β信号调控着后生动物胚胎发育、组织稳态和损伤修复。TGF-β信号传导缺陷，尤其是在上皮细胞、组织成纤维细胞和免疫细胞中，会破坏免疫耐受性，促进炎症，导致纤维化和癌症发生的病因，并促进这些疾病对治疗的抵抗性。在本文中，我们将回顾TGF-β如何在健康和疾病中协调多细胞应答程序，以及如何利用这些知识来开发TGF-β系统疾病的治疗方法。此文为2023年The Authors发表。Elsevier Inc版权所有。

The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity. TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immune surveillance of multiple cell types in shared ecosystems. Defects of TGF-β signaling, particularly in epithelial cells, tissue fibroblasts, and immune cells, disrupt immune tolerance, promote inflammation, underlie the pathogenesis of fibrosis and cancer, and contribute to the resistance of these diseases to treatment. Here, we review how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.