金纳米粒子作为肿瘤诊断和治疗药物已被广泛研究。金纳米粒子由于其独特的亚细胞大小和良好的生物相容性成为理想的药物传递载体。壳聚糖、琼脂、复方藻酸、多糖、卡拉胶、乌尔汗和海藻酸钠均为生物活性高分子的示例。由于它们具有生物相容性、可降解性和无刺激性，因此在生物医学和大分子中具有广泛的应用。这些化合物的多样性得以增强，因为它们可以通过磺化、乙酰化和羧化等官能团进行修饰。在生态友好的制备过程中，通过使用多糖对金纳米粒子进行官能化，可以提高其生物相容性和靶向性。本文提供了关于使用基于碳水化合物的金纳米粒子在肝癌治疗、成像和药物给予方面的最新进展。重点关注了几种碳水化合物的选择性表面修饰和金纳米粒子的其他生物学用途。版权所有 © 2023。Elsevier B.V.出版。

Gold nanoparticles have been broadly investigated as cancer diagnostic and therapeutic agents. Gold nanoparticles are a favorable drug delivery vehicle with their unique subcellular size and good biocompatibility. Chitosan, agarose, fucoidan, porphyran, carrageenan, ulvan and alginate are all examples of biologically active macromolecules. Since they are biocompatible, biodegradable, and irritant-free, they find extensive application in biomedical and macromolecules. The versatility of these compounds is enhanced because they are amenable to modification by functional groups like sulfation, acetylation, and carboxylation. In an eco-friendly preparation process, the biocompatibility and targeting of GNPs can be improved by functionalizing them with polysaccharides. This article provides an update on using carbohydrate-based GNPs in liver cancer treatment, imaging, and drug administration. Selective surface modification of several carbohydrate types and further biological uses of GNPs are focused on.Copyright © 2023. Published by Elsevier B.V.