多发性骨髓瘤（MM）是一种属于浆细胞增多症类别的造血系统恶性肿瘤。MM常见的口腔表现包括下颌骨和上颌骨的破骨性损害，可表现为疼痛性骨肿块、牙龈肿物形成或突发牙齿移动。MM的治疗是由多学科团队协调进行的，并依赖于患者的年龄和身体状况，以及疾病的分期。大部分患者将接受静脉用双磷酸盐治疗，如帕米膦酸和左旋氨膦酸，这会使患者患上药物相关性颌骨坏死（MRONJ）的风险增加。版权所有 © 2023 Elsevier Inc. 保留所有权利。

Multiple myeloma (MM) is a hematologic malignancy belonging to a class of disorders known as plasma cell dyscrasias. Common oral manifestations of MM include osteolytic lesions in the mandible and maxilla that can present as painful bony swellings, epulis formation, or sudden teeth movement. MM treatment is coordinated by a multidisciplinary team and is dependent upon the age and physical fitness of the patient, as well as the staging of the disease. A large proportion will be treated with intravenous bisphosphonates, such as pamidronate and zoledronic acid, which places the patients at high risk for developing medication-related osteonecrosis of the jaw (MRONJ).Copyright © 2023 Elsevier Inc. All rights reserved.