维生素D缺乏在人群中很常见，但其与绝经后女性的死亡率之间的关系尚不清楚。本研究的目的是探讨血清25-羟基维生素D（25(OH)D）与美国绝经后妇女的总体和特定死亡率之间的关联。本研究纳入了来自国家健康与营养调查(NHANES)的6812名绝经后女性参与者（2001-2018年）。通过与国家死亡指数（NDI）记录的连接，确认了随访的死亡状况，截至2019年12月31日。我们使用Cox比例风险模型估计血清25(OH)D浓度与绝经后女性的死亡率的关联。血清25(OH)D的平均水平为72.57±29.93 nmol/L，65.34%的人缺乏维生素D。绝经后女性中，血清25(OH)D浓度较低与糖化血红蛋白、血糖水平较高以及高密度脂蛋白水平较低显著相关。随访期间，发生了1448例总体死亡，其中包括393例心血管疾病（CVD）相关死亡和263例癌症死亡。多变量调整后，血清25(OH)D水平升高与总体和CVD死亡率降低显著相关。此外，血清25(OH)D与总体死亡率呈L型关系，而与CVD死亡率呈U型关系，截断值分别为73.89 nmol/L和46.75 nmol/L。绝经后女性中低血清25(OH)D水平与更高的总体和CVD死亡风险相关。这些发现为绝经后妇女的健康管理提供了新的思路和目标。© 2023. BioMed Central Ltd., Springer Nature的一部分。

Vitamin D deficiency is common among the population, but its relationship with mortality of postmenopausal females is unclear. The aim of this study is to explore the association between serum 25-Hydroxyvitamin D (25(OH)D) and all-cause and cause-specific mortality among postmenopausal women in the United States.6812 participants of postmenopausal females from the National Health and Nutrition Examination Survey (2001-2018) were included in this study. The mortality status of the follow-up was ascertained by linkage to National Death Index (NDI) records through 31 December 2019. We used cox proportional hazards models to estimate the association of serum 25(OH)D concentrations and mortality of postmenopausal females.The mean level of serum 25(OH)D was 72.57 ± 29.93 nmol/L, and 65.34% had insufficient vitamin D. In postmenopausal females, low serum 25(OH)D concentrations were significantly associated with higher levels of glycohemoglobin, glucose, and lower levels of HDL. During follow-up, 1448 all-cause deaths occurred, including 393 cardiovascular disease (CVD)-related deaths and 263 cancer deaths. After multivariate adjustment, higher serum 25(OH)D levels were significantly related with lower all-cause and CVD mortality. In addition, serum 25(OH)D presented a L-shaped relationship with all-cause mortality, while appeared a U-shaped with CVD mortality, and the cut-off value is 73.89 nmol/L and 46.75 nmol/L respectively.Low serum 25(OH)D levels are associated with the higher risk of all-cause and CVD mortality in postmenopausal females. These findings provide new ideas and targets for the health management of postmenopausal women.© 2023. BioMed Central Ltd., part of Springer Nature.