研究动态
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心脏肉瘤表现为类旁肿瘤性关节炎和蒲扇指:病例报告和文献综述。

Cardiac sarcoma presenting as paraneoplastic arthritis and clubbing: a case report and literature review.

发表日期:2023 Sep 15
作者: Natasha Ung, Carmella Gunasingam, Ken Cai, Nicholas Manolios, Angela Bayly, Phuong Dinh, Yishay Orr, Preeti Choudhary, Peter Wong
来源: Brain Structure & Function

摘要:

心脏肿瘤罕见,临床表现取决于其解剖位置。症状可能是心脏出流异常、全身特征(如发热、体重减轻)以及/或肿瘤相关病征(如关节炎)的结果。目前,仅有一份文献中报道了一例以关节炎为表现的心脏肉瘤病例报告。一名52岁女性表现为急性起病的对皮质激素抵抗的炎性多关节痛、筒状指和收缩期杂音。经胸超声心动图显示左心房扩张伴有回声异常的肿块,脑磁共振成像显示多发栓塞性梗死。紧急切除术后病理组织学检查显示为3级左心房内膜肉瘤。肿瘤摘除后多关节痛和筒状指迅速缓解。该患者随后接受了化疗并保持缓解状态。该病例突出了心脏肉瘤与关节病的罕见肿瘤相关性。© 2023. BioMed Central Ltd., part of Springer Nature.
Cardiac tumours are rare, and clinical manifestations depend on the anatomical location. Symptoms can be the result of cardiac outflow anomalies, constitutional features such as fever, loss of weight, and/or paraneoplastic manifestations such as arthritis. To date, there has only been one other case report in the literature of cardiac sarcoma presenting as paraneoplastic arthropathy.A 52-year-old woman presented with acute onset corticosteroid-resistant inflammatory polyarthralgia, clubbing and a systolic murmur. Transthoracic echocardiogram revealed a dilated left atrium with an echogenic mass and brain magnetic resonance imaging revealed multiple embolic infarcts. Histopathology following emergency resection showed a Grade 3 left atrial intimal sarcoma. The polyarthralgia and clubbing resolved soon after tumour removal. The patient went on to receive chemotherapy and remains in remission.This case highlights the rare paraneoplastic association of cardiac sarcoma and arthropathy.© 2023. BioMed Central Ltd., part of Springer Nature.