爱泼斯坦-巴尔病毒是一种人类伽马疱疹病毒，与癌症和其他疾病的发病机制密切相关，这些疾病是全世界公共卫生的负担。到目前为止，已经发现了几种可以靶向EBV编码产物进行治疗的药物或生物分子，例如Silvestrol、亲和毒素、roscovitine、H20、H31、姜黄素、百里醌和核糖体蛋白L22。这些药物激活或抑制某些生物分子的功能，通过作用于EBV的产物来影响后续的信号通路。这些药物通常针对LMP1、LMP2； EBNA1、EBNA2、EBNA3； EBER1、EBER2； Bam-HI A 向右转录本和 BHRF1。此外，在疫苗、免疫学和细胞疗法领域也取得了一些有希望的发现。在这篇综述中，我们主要总结了上述药物的功能和独特机制，希望能够为治疗 EBV 相关疾病的药物设计提供帮助。© 2023 John Wiley

Epstein-Barr virus, a human gamma-herpesvirus, has a close connection to the pathogenesis of cancers and other diseases, which are a burden for public health worldwide. So far, several drugs or biomolecules have been discovered that can target EBV-encoded products for treatment, such as Silvestrol, affinity toxin, roscovitine, H20, H31, curcumin, thymoquinone, and ribosomal protein L22. These drugs activate or inhibit the function of some biomolecules, affecting subsequent signalling pathways by acting on the products of EBV. These drugs usually target LMP1, LMP2; EBNA1, EBNA2, EBNA3; EBER1, EBER2; Bam-HI A rightward transcript and BHRF1. Additionally, some promising findings in the fields of vaccines, immunological, and cellular therapies have been established. In this review, we mainly summarise the function of drugs mentioned above and unique mechanisms, hoping that we can help giving insight to the design of drugs for the treatment of EBV-associated diseases.© 2023 John Wiley & Sons Ltd.