评估病理性骨折的发生率和相关因素及其对姑息治疗下骨转移患者总体生存的影响。一项针对姑息治疗下出现骨转移的男性和女性癌症患者的观察性回顾性队列评估护理单位。在转诊至护理单位之前和之后获得了社会人口统计学和临床​​数据。对患者进行随访直至死亡或最后一次随访（转诊后 4 年）。应用逻辑回归模型和采用对数秩检验的生存曲线。该研究总共包括 348 名患者。大多数患者年龄<65岁（65%）和女性（62%），最常见的原发肿瘤部位是乳房（40%）。病理性骨折的发生率为 28%，中轴骨骼的发生率更高 (49%)，与患者总生存率无关 (p=0.348)。与其他肿瘤患者相比，乳腺癌患者发生骨折的几率高出 2.96 倍（95%CI：1.80 至 4.86），而之前未接受放射治疗的患者发生骨折的几率高出 5.60 倍（95%CI：2.46）。至 12.77)。观察到病理性骨折的发生率很高。患有乳腺癌并且之前未接受过放射治疗会增加骨折发生的机会，尽管这与接受姑息治疗的患者的总体生存率无关。© 作者（或其雇主）2023。没有商业重新使用。请参阅权利和权限。由英国医学杂志出版。

To assess the prevalence and factors associated with the occurrence of pathological fractures and their impact on the overall survival of patients with bone metastases under palliative care.An observational retrospective cohort assessment concerning both male and female patients with cancer presenting with bone metastases referred to a palliative care unit. Sociodemographic and clinical data were obtained before and after care unit referral. Patients were followed up until death or the last follow-up (4 years after referral). Logistic regression models and survival curves employing a log-rank test were applied.A total of 348 patients were included in the study. Most were <65 years (65%) and female (62%), and the most frequent primary tumour site was the breast (40%). The prevalence of pathological fractures was 28%, more frequent in the axial skeleton (49%), with no association with overall patient survival (p=0.348). Patients with breast cancer exhibited a 2.96-fold higher chance (95% CI: 1.80 to 4.86) of developing a fracture compared with other tumours, and not receiving previous radiotherapy increased the chances of fracture occurrence by 5.60-fold (95% CI: 2.46 to 12.77).A high prevalence of pathological fractures was observed. Presenting with breast cancer and not having undergone previous radiotherapy increase the chances of fracture occurrence, although this is not associated with overall survival in patients under palliative care.© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.