口腔扁平苔藓（OLP）可能会增加慢性牙周炎的风险，目前尚无报道显示患有牙周炎的OLP患者是否有更大的口腔癌前病变、念珠菌感染或其他临床病理疾病的风险。本研究旨在评估台湾南部 293 名患有或不患有慢性牙周炎的 OLP 患者发生口腔癌前病变的危险因素。本研究招募了 1995 年至 2018 年在三级机构就诊的 293 名未患有牙周炎的 OLP 患者。根据是否存在牙周炎将患者分为两组。该研究比较了两组之间的各种临床和病理特征，并分别使用logistic回归模型和Kaplan-Meier分析方法估计了OLP患者的比值比（OR）和慢性牙周炎的10年累积风险。对于年龄和性别，OLP患者口腔癌前病变的显着影响因素（P < 0.05）是牙周病（OR = 2.24）和男性（OR = 7.52）。槟榔摄入量 (OR = 2.61)、吸烟 (OR = 2.46) 和念珠菌病感染 (OR = 3.02) 也显示出显着关联。年龄较大的 OLP 患者病变风险较低，而较长的 OLP 持续时间会增加患牙周病的可能性。本研究表明，共存的牙周病会增加 OLP 患者发生癌前病变的可能性。牙周管理、口腔卫生护理以及戒掉槟榔和吸烟可以降低风险。© 2023 中华民国牙科科学协会。 Elsevier B.V. 的出版服务

Oral lichen planus (OLP) may contribute to the risk of chronic periodontitis, and no reports have shown whether OLP patients with periodontitis have a greater risk of oral precancerous lesions, Candida infection or other clinicopathological diseases. This study aimed to assess the risk factors for the development of oral precancerous lesions in a cohort of 293 OLP patients with or without chronic periodontitis in southern Taiwan.The current study recruited 293 OLP patients without preexisting periodontitis at a tertiary institution from 1995 to 2018. The patients were divided into two groups based on the presence or absence of periodontitis. The study compared various clinical and pathological characteristics between the two groups, and also estimated the odds ratio (OR) and the 10-year cumulative risk of chronic periodontitis in OLP patients using logistic regression models and Kaplan‒Meier analysis methods, respectively.After adjusting for age and gender, the significant contributors to oral precancerous lesions in OLP patients (P < 0.05) were periodontal disease (OR = 2.24) and the male gender (OR = 7.52). Betel nut consumption (OR = 2.61), smoking (OR = 2.46), and candidiasis infection (OR = 3.02) also showed significant associations. Older OLP patients had a lower lesion risk, while a longer OLP duration heightened the periodontal disease likelihood.The present study demonstrated that coexisting periodontal disease increases the likelihood of developing precancerous lesions in patients with OLP. Periodontal management with oral hygiene care and quitting betel nut consumption and smoking can reduce the risk.© 2023 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.