结直肠癌（CRC）是发达国家第三大常见恶性肿瘤。因此，omega-3 脂肪酸 (O3FA) 因其调节炎症反应和改善营养水平的能力而被建议作为有益的补充治疗。本研究旨在评估 O3FA 作为炎症、营养水平、营养水平的补充治疗的效果。术后感染并发症，以及促进结直肠癌患者的康复。通过三个数据库进行文献检索。通过测量促炎细胞因子（IL-1β、IL-6 和 TNF-α）和 CRP 水平、用于营养评估的血清白蛋白水平、术后感染并发症以及用于恢复评估的住院时间来评估感兴趣的结果。分别使用RoB 2.0和RevMan 5.4进行质量评价和荟萃分析。结果显示O3FAs显着降低IL-6、CRP和TNF-α，但不影响IL-1β。此外，血清白蛋白水平略有增加，补充导致术后感染并发症减少并缩短住院时间。O3FA作为补充治疗为结直肠癌患者提供了优势，还应进行进一步的临床试验和实验来强调其影响以及 O3FA 在 CRC 患者营养状况中的临床实施。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Colorectal cancer (CRC) is the third most common malignancy in developed countries. Therefore, omega-3 fatty acids (O3FAs) have been suggested as a beneficial complementary treatment due to their ability to regulate inflammatory responses and improve nutrition levels.This study aimed to evaluate the effects of O3FAs as a complementary treatment for inflammation, nutrition levels, post-operative infectious complications, and enhancement of recovery in CRC patients.The literature search was carried out through three databases. The outcomes of interest were assessed by measuring pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) and CRP levels, serum albumin levels for nutrition assessment, post-operative infectious complications, and length of stay for recovery evaluation. Quality appraisal and meta-analysis were performed using RoB 2.0 and RevMan 5.4, respectively.The result showed that O3FAs significantly reduced IL-6, CRP, and TNF-α, but did not affect IL-1β. Furthermore, the variable slightly increased serum albumin levels and the supplementation led to a decrease in post-operative infectious complications and shortened hospital stays.O3FAs as a complementary treatment provided advantages for CRC patients, Further clinical trials and experiments should also be made emphasizing the impact and clinical implementation of O3FA in the nutritional status of CRC patients.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.