多项研究表明，脂肪因子与癌症类型相关，并被证明在癌症生物学中有效。本研究旨在确定 vaspin rs2236242 多态性与 vaspin 水平与甲状腺乳头状癌 (PTC) 和多结节性甲状腺肿 (MNG) 之间的关系。在这项横断面研究中，我们招募了 170 名候选人。伊朗德黑兰 Shariati 医院的 90 名新诊断患者（PTC 60 名患者和 MNG 30 名患者）和 80 名作为对照组的参与者参加了这项研究。使用 Elisa 试剂盒进行 Vaspin 激素测量。采用Tetra扩增抗突变系统聚合酶链式反应（T-ARMS-PCR）测定单核苷酸多态性（SNP）rs2236242的基因型。使用 SPSS 软件版本 20 进行统计分析。我们的研究结果显示三组中存在显着的年龄和基因型频率差异（p 值 < 0.05）。 PTC 组和对照组之间的 vaspin 水平没有显着差异。 MNG中vaspin的水平与对照组相比有显着差异，但调整年龄后没有差异。结果显示vaspin rs2236242多态性基因型与vaspin水平无关。 PTC组和MNG组中vaspin rs2236242的基因型和等位基因频率与对照组相比显着。我们发现 vaspin rs2236242 基因多态性可作为甲状腺乳头状癌的潜在标志物。 vaspin SNP rs2236242 的 A 等位基因对 PTC 和 MNG 具有保护作用。 rs2236242 处的 SNP 与 vaspin 水平没有显着相关。

Several studies showed that adipokines are associated with types of cancer which are documented to be effective in cancer biology. This study aimed to determine the relationship between vaspin rs2236242 polymorphism and the vaspin level with papillary thyroid carcinoma (PTC), and multinodular goiter (MNG). In this cross-sectional study, we recruited 170 candidates. Ninety patients with newly diagnosed (PTC 60 patients and MNG 30 patients), and 80 participants as a control group referred to Shariati Hospital, Tehran, Iran, were enrolled in the study. The vaspin hormone measurements were conducted utilizing the Elisa Kit. Using Tetra amplification resistant-mutation system polymerase chain reaction (T-ARMS-PCR), the genotype of single nucleotide polymorphism (SNP) rs2236242 was determined. The statistical analysis was performed using SPSS software version 20. Our findings showed significant age and genotype frequency differences in three groups (p-value < 0.05). There was no significant difference in vaspin levels between PTC, and control groups. The level of vaspin in MNG compared to the control group had significantly different, but there were no differences after adjustment for age. Results showed the genotypes of vaspin rs2236242 polymorphism are not associated with the level of vaspin. The genotypes and allele frequencies of vaspin rs2236242 in the PTC and MNG groups were significant compared to the control group. We have found vaspin rs2236242 gene polymorphism as a potential marker of papillary thyroid cancer. The A allele of the vaspin SNP rs2236242 plays a protective role against PTC and MNG. SNP at rs2236242 was not significantly associated with vaspin levels.