根据番石榴叶提取物不同提取物（NC：未浓缩，C10和C20：纳滤浓缩）的总酚化合物（TPC）含量和抗氧化活性以及它们对 A549 和 Vero 细胞的细胞毒性作用。结果表明，C10和C20在125天内表现出较高的稳定性，这可能是由于它们的高TPC含量和抗氧化活性。模拟胃肠道行为改变了它们的TPC含量；然而，在所有消化步骤之后，TPC值高于70%，这意味着它们仍然可以发挥其生物活性。此外，在模拟胃肠道行为之前和之后或在不同的储存条件下评估了这些提取物的细胞毒性作用。 C10 在两种条件下均呈现出最佳选择性指数 (SI) 值（IC50 Vero 细胞/IC50 A549 细胞），这表明由于其对胃肠道消化和测试储存条件的耐受性，可以将其视为开发为功能性食品的潜在提取物。

The influence of storage stability and simulated gastrointestinal behavior of different extracts of guava leaves extracts (NC: not concentrated, and C10 and C20: concentrated by nanofiltration) was evaluated based on their total phenolic compound (TPC) contents and antioxidant activity as well as on their cytotoxic effects on A549 and Vero cells. The results showed that C10 and C20 presented high stability for 125 days probably due to their high TPC contents and antioxidant activity. The simulated gastrointestinal behavior modified their TPC contents; however, after all digestion steps, the TPC values were higher than 70%, which means that they were still available to exert their bioactivities. Additionally, the cytotoxic effects of these extracts were evaluated before and after the simulated gastrointestinal behavior or under different storage conditions. C10 presented the best selectivity indices (SI) values (IC50 Vero cells/IC50 A549 cells) at both conditions suggesting that it can be considered a potential extract to be developed as a functional food due to its resistance to the gastrointestinal digestion and storage conditions tested.