恶性胸腔积液（MPE）是晚期恶性肿瘤常见的并发症。临床研究表明，注射用香菇多糖（LNT）有利于改善患者的生活质量，延长患者的生存期。本次荟萃分析的目的是评价LNT联合顺铂治疗MPE的有效性和安全性。自2017年建立以来，在6个文献数据库中检索了LNT联合顺铂治疗MPE的随机对照试验（RCT）。每个数据库由 2 位研究人员负责。根据纳入标准，2名研究者独立筛选研究，评估偏倚风险，并根据纳入文献的具体特点对不同结局指标进行亚组分析。采用Revman软件对数据进行分析，并采用Stata软件评价结果的稳定性。共纳入52个RCT。结果显示LNT联合顺铂可提高治疗效果，组间差异有统计学意义（RR = 1.40，95%CI：1.33～1.46，P < .001）。联合使用LNT可提高生活质量（RR = 1.45，95%CI：1.35～1.56，P < .001）。使用LNT可显着降低胃肠道反应发生率（RR = 0.86，95%CI：0.78～0.94，P < .001）。敏感性分析结果显示该指标无质变，提示可能存在发表偏倚。现有证据表明LNT联合顺铂治疗MPE的疗效优于单用顺铂，且不增加ADR发生率。 LNT是MPE的理想治疗方法，具有很高的临床应用价值。Copyright © 2024 the Author(s).由 Wolters Kluwer Health, Inc. 出版

Malignant pleural effusion (MPE) is a frequently observed complication in advanced malignant tumors. Clinical studies have shown that lentinan for injection (LNT) is beneficial for improving patients' quality of life and prolonging their survival. The purpose of this meta-analysis is to evaluate the efficacy and safety of LNT combining cisplatin in the treatment of MPE.Randomized controlled trials (RCTs) of LNT combining cisplatin in the treatment of MPE were searched in 6 literature databases from the establishment time of each database by 2 researchers. According to the inclusion criteria, 2 researchers independently screened studies, assessed the risk of bias and conducted subgroup analyses for different outcome indicators according to the specific characteristics of the included literature. Analyzing the data by Revman software, and evaluating the stability of the results by Stata software.A total of 52 RCTs were included. The results showed that combined use of LNT and cisplatin could improve the treatment effect, and the difference between groups was statistically significant (RR = 1.40, 95%CI: 1.33 ~ 1.46, P < .001). And the combined use of LNT could increase the quality of life (RR = 1.45, 95%CI: 1.35 ~ 1.56, P < .001). The using of LNT could significantly decrease the incidence of gastrointestinal reactions (RR = 0.86, 95%CI: 0.78 ~ 0.94, P < .001). Sensitivity analysis results showed that there were no qualitative changes in the indicator, and suggested the possibility of publication bias.Available evidence suggested the combined use of LNT and cisplatin showed better efficacy in treating MPE without increasing ADR incidence than using cisplatin alone. LNT is an ideal treatment for MPE, which has high clinical application value.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.