乳腺癌是全世界女性最常见的癌症，对公共健康构成重大威胁。本研究旨在对激素避孕药的使用与乳腺癌发病率之间的关系进行系统回顾。搜索是使用 Google Scholar、Proquest、Pubmed 和印尼数据库 Garuda 进行的，使用英语和印尼语关键词。本研究的纳入标准为最近五年的发表年份，即2019-2023年，英语和印尼语，病例对照观察研究，使用印尼人群，全文获取。共获得165项研究来自 Google Scholar 数据库，包括 104 项研究。总体多变量分析显示，激素避孕与乳腺癌发病率存在统计学显着相关性，OR 值在 2-6 范围内。这项系统研究的结果表明，激素的使用会导致激素失衡，进一步增加乳腺细胞增殖并破坏基因表达，导致细胞发育失控/癌症。此外，研究结果建议增加有关该主题的研究数量，以获得更充分且可能更多样化的信息。

Breast cancer is the most common cancer in women worldwide and is a significant threat to public health. This study aims to conduct a systematic review of the relationship between hormonal contraceptive use and breast cancer incidence.The search was conducted using Google Scholar, Proquest, Pubmed and one Indonesian database, Garuda, using English and Indonesian keywords. The inclusion criteria in this study were the publication year of the last five years, namely 2019-2023, English and Indonesian language, case-control observational research, using the Indonesian population, and full-text access.A total of 165 studies were obtained from the Google Scholar database, including 104 studies. The overall multivariate analysis revealed that there was a statistically significant association of hormonal contraception with the incidence of breast cancer with OR values in the range of 2-6.The findings of this systematic study suggest that the use of hormones can contribute to hormonal imbalances that further increase breast cell proliferation and disrupt gene expression, resulting in uncontrolled cell development/cancer. In addition, the findings recommend increasing the number of studies on this topic to obtain more adequate and possibly more diverse information.