研究动态
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应对年轻人的非小细胞肺癌:从危险因素和遗传易感性到肺癌概况和结果。

Tackling Non-Small Cell Lung Cancer in Young Adults: From Risk Factors and Genetic Susceptibility to Lung Cancer Profile and Outcomes.

发表日期:2024 Jun
作者: Juan Carlos Laguna, Marco Tagliamento, Matteo Lambertini, James Hiznay, Laura Mezquita
来源: MOLECULAR & CELLULAR PROTEOMICS

摘要:

传统上,肺癌与高龄有关。然而,该病在年轻人中的发病率不断增加,引发了有关其病因学和针对该人群的独特考虑的问题。与老年人群相比,肺癌在年轻时的发病可能是由于不完全了解的个人易感性和烟草烟雾暴露之外的普遍环境风险因素(例如全球普遍存在的氡气和空气污染)之间复杂的相互作用所致。因此,这会导致不同的临床和分子特征,需要量身定制的方法。此外,癌症的诊断代表着年轻人生命中黄金时期的威胁事件,引发了对职业发展、社会方面、生育愿望和身体独立的担忧。这给这个尚未充分探索的领域的医疗保健专业人员带来了重大的额外挑战。这篇全面的综述将年轻人肺癌视为一个独特的实体,探讨其临床和分子特征、不同的诱发因素以及生活质量方面的优先事项,旨在为肿瘤学家提供实际支持,并加深我们对此的理解。 - 研究人群。
Lung cancer has traditionally been associated with advanced age; however, its increasing incidence among young adults raises concerning questions regarding its etiology and unique considerations for this population. In contrast to the older population, the onset of lung cancer at younger age may be attributed to a complex interplay of incompletely understood individual susceptibility and prevalent environmental risk factors beyond tobacco smoke exposure, such as radon gas and air pollution, which are widespread globally. Consequently, this leads to distinct clinical and molecular profiles, requiring a tailored approach. Furthermore, a diagnosis of cancer represents a threatening event during the prime years of a young person's life, prompting concern about career development, social aspects, fertility aspirations, and physical independence. This poses significant additional challenges for health care professionals in a field that remains underexplored. This comprehensive review recognizes lung cancer in young adults as a distinct entity, exploring its clinical and molecular characteristics, diverse predisposing factors, and priorities in terms of quality of life, with the aim of providing practical support to oncologists and enhancing our understanding of this under-researched population.