外泌体是细胞分泌的内源性囊泡，具有生物相容性高、免疫原性低、靶向能力强、半衰期长、血脑屏障通透性等独特特性。它们在生理过程和疾病发生中充当重要的细胞间通讯载体。我们对 2013 年至 2023 年基于外泌体的药物递送研究的全面分析显示，有来自 33 个国家 717 个机构的 2,476 名作者。关键词聚类确定了五个研究领域：药物递送、间充质干细胞、癌症免疫治疗、靶向配体、表面修饰和巨噬细胞。外泌体药物递送技术与经过验证的临床模型相结合，能够利用化疗或放射增敏剂精确靶向肿瘤，并促进基因治疗。该文献计量分析旨在描述当前状态并推进基于外泌体的药物输送系统的临床应用。版权所有 © 2024 作者。由 Elsevier Masson SAS 出版。保留所有权利。

Exosomes, endogenous vesicles secreted by cells, possess unique properties like high biocompatibility, low immunogenicity, targeting ability, long half-life, and blood-brain barrier permeability. They serve as crucial intercellular communication vectors in physiological processes and disease occurrence. Our comprehensive analysis of exosome-based drug delivery research from 2013 to 2023 revealed 2,476 authors from 717 institutions across 33 countries. Keyword clustering identified five research areas: drug delivery, mesenchymal stem cells, cancer immunotherapy, targeting ligands, surface modifications, and macrophages. The combination of exosome drug delivery technology with a proven clinical model enables the precise targeting of tumors with chemotherapy or radiosensitising agents, as well as facilitating gene therapy. This bibliometric analysis aims to characterize the current state and advance the clinical application of exosome-based drug delivery systems.Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.