新的证据表明，长链非编码 RNA (lncRNA) 的失调与胰腺癌 (PC) 有关。但LINC00930在PC中的功能尚未详细阐述。在这项研究中，我们发现LINC00930在PC细胞系和组织中显着下调，并且与肿瘤大小、淋巴转移、TNM分期和不良预后相关。根据生物信息学数据库，LINC00930的下调是PC中与预后和EMT相关的常见事件。 LINC00930 的过表达可在体外和体内抑制 PC 的侵袭性癌症表型，包括增殖、转移和上皮间质转化 (EMT)。生物信息学和双荧光素酶报告基因分析表明miR-6792-3p可以直接结合LINC00930。此外，含有锌指和BTB结构域16（ZBTB16）的PC中显着下降，这被预测为miR-6792-3p的下游基因。 MiR-6792-3p 模拟物可挽救 ZBTB16 在 PC 细胞中引起的增殖、转移和 EMT 减少。 LINC00930/miR-6792-3p/ZBTB16轴与PC的恶性进展和过程相关。 LINC00930的相对表达量与miR-6792-3p的表达量呈负相关，并与PC中ZBTB16的水平密切相关。 LINC00930 可能作为 PC 的潜在预后生物标志物和治疗靶点。© 2024。作者。

Emerging evidence suggests the dysregulation of long non-coding RNAs (lncRNAs) involved in pancreatic cancer (PC). However, the function of LINC00930 in PC has not been elaborated. In this study, we found that LINC00930 was significantly down-regulated in PC cell lines and tissues, and associated with tumor size, lymphatic metastasis, TNM stage and poor prognosis. According to the bioinformatics database, the downregulation of LINC00930 was a common event in PC associated with prognosis and EMT. Overexpression of LINC00930 inhibited the aggressive cancer phenotypes including proliferation, metastasis and epithelial-mesenchymal transition (EMT) of PC in vitro and in vivo. Bioinformatics and dual-luciferase reporter assay indicated that miR-6792-3p could directly bind to LINC00930. Additionally, the Zinc finger and BTB domain containing 16 (ZBTB16) was significantly declined in PC, which was predicted to be the downstream gene of miR-6792-3p. MiR-6792-3p mimic rescued the decreased proliferation, metastasis and EMT caused by ZBTB16 in PC cells. The LINC00930/miR-6792-3p/ZBTB16 axis was associated with the malignant progression and process of PC. The relative expression of LINC00930 was negatively correlated with the expression of miR-6792-3p and was closely linked with ZBTB16 levels in PC. LINC00930 might serve as a potential prognostic biomarker and therapeutic target for PC.© 2024. The Author(s).