转座元件 (TE) 的特点是能够改变其基因组位置。通过插入或重组导致缺失和其他染色体畸变，它们可能导致遗传不稳定。它们对细胞功能发挥调节影响的程度尚不清楚。为了更好地表征癌发生等过程中的 TE，我们使用了完善的剑尾黑色素瘤模型。通过转录组测序，我们发现转座子总数的增加与剑尾鱼种间杂种黑色素瘤样本中的恶性进展相关。此外，通过比较剑尾鱼和剑尾鱼亲本基因组中 TE 的存在情况，我们可以表明，即使在密切相关的物种中，TE 的基因组位置和谱也有很大不同。

Transposable elements (TEs) are characterized by their ability to change their genomic position. Through insertion or recombination leading to deletions and other chromosomal aberrations, they can cause genetic instability. The extent to which they thereby exert regulatory influence on cellular functions is unclear. To better characterize TEs in processes such as carcinogenesis, we used the well-established Xiphophorus melanoma model. By transcriptome sequencing, we show that an increasing total number in transposons correlates with progression of malignancy in melanoma samples from Xiphophorus interspecific hybrids. Further, by comparing the presence of TEs in the parental genomes of Xiphophorus maculatus and Xiphophorus hellerii, we could show that even in closely related species, genomic location and spectrum of TEs are considerably different.