1 型毛鼻指综合征 (TRPS1) 已成为一种可靠的免疫组织化学 (IHC) 标记物，用于识别转移性癌中的乳腺起源。本研究调查了 TRPS1 IHC 在非乳腺细胞学标本中的效用。对我们 2021 年的病理学数据库进行回顾性搜索，确定了液体（胸膜和腹膜）以及肝脏、肺和骨细针抽吸 (FNA) 以及手术随访确认非乳腺癌转移癌。使用针对人 TRPS1 的兔多克隆抗体对来自具有足够肿瘤细胞的病例的细胞块进行免疫染色。最初检查后深层缺乏肿瘤的病例被排除在研究之外。两名病理学家独立解释TRPS1染色。在评估的136例中，31例（22.79%）显示TRPS1染色阳性，而105例（77.21%）无反应。在苗勒管细胞来源、胃肠道 (GIT) 和肺来源的肿瘤中观察到的阳性率分别为 28.85%、25% 和 21.57%。苗勒管细胞来源的肿瘤中，浆液性癌10例（66.67%），子宫内膜样癌4例（26.67%），透明细胞癌1例（6.67%）。肺部肿瘤包括 7 例（63.64%）鳞状细胞癌和 4 例（36.36%）腺癌，而胃肠道肿瘤包括 14 例（80%）腺癌和 1 例（20%）鳞状细胞癌。尽管被认为是乳腺癌的敏感标志物, TRPS1 免疫染色也在苗勒管癌、肺癌和胃肠道癌中检测到。这凸显了仅依靠 TRPS1 免疫染色来区分转移性乳腺肿瘤时要谨慎的重要性。© 2024 Wiley periodicals LLC。

Trichorhinophalangeal syndrome type 1 (TRPS1) has emerged as a reliable immunohistochemistry (IHC) marker for identifying breast origin in metastatic carcinomas. This study investigates the utility of TRPS1 IHC in non-breast cytology specimens.A retrospective search of our pathology database for the year 2021 identified fluids (pleural and peritoneal) and liver, lung and bone fine needle aspirations (FNAs) with surgical follow-up confirming non-breast metastatic carcinomas. Cell blocks from cases with sufficient neoplastic cells underwent immunostaining using a rabbit polyclonal antibody against human TRPS1. Cases lacking tumor on deeper levels after the original work-up were excluded from the study. Two pathologists independently interpreted the TRPS1 staining.Of 136 cases assessed, 31 (22.79%) exhibited positive TRPS1 staining, while 105 (77.21%) were nonreactive. Positivity rates were observed in tumors of Mullerian cell origin, gastrointestinal tract (GIT), and lung origin at 28.85%, 25%, and 21.57%, respectively. Of the tumors of Mullerian cell origin 10 (66.67%) were serous carcinomas, 4 (26.67%) were endometrioid carcinomas, and one (6.67%) was a clear cell carcinoma. Lung tumors comprised seven (63.64%) squamous cell carcinomas and four (36.36%) adenocarcinomas, while the gastrointestinal tumors consisted of 14 (80%) adenocarcinomas and one (20%) squamous cell carcinoma.Although recognized as a sensitive marker for mammary carcinomas, TRPS1 immunostaining was also detected in Mullerian, lung, and GIT carcinomas. This highlights the significance of being cautious when depending solely on TRPS1 immunostaining to distinguish metastatic breast tumors.© 2024 Wiley Periodicals LLC.