棕色肿瘤是由甲状旁腺功能亢进引起的反应性溶骨性病变。这些罕见的病变是由骨吸收引起的非肿瘤过程。本研究的目的是回顾性回顾我机构 34 年的棕色肿瘤治疗经验。我们回顾性分析了 1988 年 5 月至 2020 年 10 月期间在我机构治疗的连续 26 例棕色肿瘤患者的记录，平均随访时间长达 36.1 个月。该研究包括 17 名男性 (65.4%) 和 9 名女性 (34.6%) 患者，平均年龄为 41.6 岁。 13 例 (50.0%) 患者以局部骨痛为首发症状。 3 名患者 (11.5%) 出现弥漫性骨痛。 7 名患者 (26.9%) 在接受病理性骨折检查时被诊断患有棕色肿瘤。其他 3 名患者 (11.5%) 在评估高钙血症症状时被诊断出来。 7 名患者 (26.9%) 为单发病变，19 名患者 (73.1%) 为多发性病变。骨盆、股骨、肋骨、胫骨、肱骨近端和下颌骨是最常见的定位部位。 23 名患者（88.5%）被诊断为原发性甲状旁腺功能亢进症，另外 3 名患者（11.5%）患有继发性甲状旁腺功能亢进症。共65个病灶，23个（35.4%）接受矫形手术，42个（64.6%）甲状旁腺切除术后保守随访。 26例患者中21例行骨科手术，其余5例行保守随访。 19例（82.6%）进行了病灶内刮除术。 11 例（47.8%）所形成的空洞被骨水泥填充。 8例（34.8%）采用骨移植。所有患者均未观察到复发。棕色肿瘤的诊断始于临床怀疑。手术前内分泌科和普外科咨询很重要。棕色肿瘤的治疗需要多学科方法。© 2024。作者。

Brown tumors are reactive osteolytic lesions caused by hyperparathyroidism. These rare lesions are non-neoplastic processes that result from bone resorption. The purpose of this study was to retrospectively review a 34-year experience with brown tumors in our institution.We retrospectively analyzed the records of 26 consecutive patients with brown tumor who were treated in our institution between May 1988 and October 2020, with a mean follow-up of 36,1 months.17 male (65,4%) and 9 female (34,6%) patients with a mean age of 41,6 were included in the study. Localized bone pain was present in 13 cases (50,0%) as the first presenting symptom. 3 patients (11,5%) presented with diffuse bone pain. 7 patients (26,9%) were diagnosed with brown tumor while being investigated for pathological fractures. The other 3 patients (11,5%) were diagnosed while being evaluated for hypercalcemia symptoms. 7 patients (26,9%) had solitary lesions, while 19 patients (73,1%) had multiple lesions. Pelvis, femur, ribs, tibia, proximal humerus and mandible were the most common sites of localization. 23 patients (88,5%) were diagnosed with primary hyperparathyroidism, while the other 3 patients (11,5%) had secondary hyperparathyroidism. A total of the 65 lesions, 23 (35.4%) underwent orthopedic surgery, and 42 (64.6%) were followed up conservatively after parathyroidectomy. Orthopedic surgery was performed in 21 of 26 patients, the other 5 cases were followed up conservatively. Intralesional curettage was performed in 19 cases (82,6%). The resulting cavity was filled with bone cement in 11 cases (47,8%). Bone grafting was applied in 8 cases (34,8%). No recurrence was observed in any of the patients.The diagnosis of brown tumor begins with clinical suspicion. Endocrinology and general surgery consultation is important before surgery. Treatment of brown tumors requires a multidisciplinary approach.© 2024. The Author(s).