使用靶向金纳米颗粒治疗艾利希癌的二元质子疗法。
Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles.
发表日期：2024 Jun
作者：
M V Filimonova, D D Kolmanovich, G V Tikhonowski, D S Petrunya, P A Kotelnikova, A A Shitova, O V Soldatova, A S Filimonov, V A Rybachuk, A O Kosachenko, K A Nikolaev, G A Demyashkin, A A Popov, M S Savinov, A L Popov, I V Zelepukin, A A Lipengolts, K E Shpakova, A V Kabashin, S N Koryakin, S M Deyev, I N Zavestovskaya
来源：
PHARMACOLOGY & THERAPEUTICS
摘要：
质子疗法可以治疗位于辐射敏感组织中的肿瘤。本文展示了利用选择性识别肿瘤细胞的靶向金纳米颗粒增强质子治疗的可能性。浓度高于 25 mg/L 和 4 Gy 质子剂量的 Au-PEG 纳米粒子在体外引起 EMT6/P 细胞完全死亡。使用靶向 Au-PEG-FA 纳米粒子的二元质子治疗在体内产生了 80% 的肿瘤生长抑制效果。使用靶向金纳米颗粒有望增强质子照射对肿瘤细胞的作用，并需要进一步研究以提高该方法的治疗指数。© 2024. Pleiades Publishing, Ltd.
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.© 2024. Pleiades Publishing, Ltd.