细胞因子阻断疗法彻底改变了银屑病和特应性皮炎的治疗，但可能导致矛盾性银屑病 (PP) 的发展。应密切监测接受生物制剂治疗的患者 PP 和其他矛盾性皮疹（包括炎症性关节病、炎症性肠病、湿疹性皮疹、狼疮样皮疹、结节性皮疹等）的发生情况，以及偶尔发生皮肤 T 细胞淋巴瘤的情况。进一步了解这些过程的免疫机制将最终推动我们对 PP 的理解以及预测和管理 PP 的能力。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Cytokine blocking therapies have revolutionized the management of psoriasis and atopic dermatitis but can lead to the development of paradoxic psoriasis (PP). Patients treated with biologics should be closely monitored for the development of PP and other paradoxical eruptions (including inflammatory joint disease, inflammatory bowel disease, eczematous eruptions, lupus like eruptions, sarcoidal eruptions, and others) and occasionally the development of cutaneous T-cell lymphoma. Further understanding the immunologic mechanism of these processes will ultimately drive our understanding of and ability to predict and manage PPs.Copyright © 2024 Elsevier Inc. All rights reserved.