研究动态
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免疫检查点抑制剂诱发的银屑病:诊断、治疗和病例回顾。

Immune Checkpoint Inhibitor-Induced Psoriasis: Diagnosis, Management, and a Review of Cases.

发表日期:2024 Jul
作者: Jolanta J Pach, Nina Mbonu, Shaman Bhullar, Jeffrey M Cohen, Jonathan S Leventhal
来源: CYTOKINE & GROWTH FACTOR REVIEWS

摘要:

免疫检查点抑制剂(ICIs)是有效的抗肿瘤药物,但与免疫相关的不良事件有关。 ICI 诱发的银屑病通常出现在有银屑病病史的患者中,但也可能从头发生,并且具有显着的身体和心理社会影响。 ICI 诱导的和非 ICI 诱导的银屑病可能由相似的细胞因子介导,并且采用相似的治疗方法。局部治疗通常就足够了,当需要时,几种全身治疗似乎是有效的,且不会影响抗肿瘤反应。牛皮癣的发展可能表明对 ICI 的反应更好。因此,识别和管理 ICI 诱发的银屑病对于避免 ICI 中断和最大限度地发挥治疗潜力至关重要。版权所有 © 2024 Elsevier Inc. 保留所有权利。
Immune checkpoint inhibitors (ICIs) are effective antitumor agents but are associated with immune-related adverse events. ICI-induced psoriasis commonly presents in patients with a history of psoriasis but may occur de novo, and it has a significant physical and psychosocial impact. ICI-induced and non-ICI-induced psoriasis are likely mediated by similar cytokines, and similar treatments are employed. Topical treatment often suffices, and when needed, several systemic treatments appear to be effective without impacting antitumor response. Development of psoriasis may indicate a superior response to ICIs. Thus, recognition and management of ICI-induced psoriasis is essential to avoid ICI interruption and maximize therapeutic potential.Copyright © 2024 Elsevier Inc. All rights reserved.