硒纳米粒子（SeNP）是一种有吸引力的靶向递送载体。硒纳米粒子因其在多种疾病中的潜在治疗应用而受到全球关注，例如类风湿性关节炎（RA）、炎症性肠病（IBD）、哮喘、肝脏以及各种自身免疫性疾病（如牛皮癣、癌症、糖尿病和各种疾病）。传染性疾病。尽管如此，最近仍然没有文献总结 SeNP 的治疗应用。需要解决一些挑战，例如寻找各种疾病中 SeNP 的靶标，以及用于提高 SeNP 稳定性、同时促进载药 SeNP 广泛分布到肿瘤区域并防止脱靶影响的各种功能化技术，需要重点了解更多关于治疗方面的信息，以便更好地理解其背后的科学。考虑到这一点，我们重点关注这一差距，并尝试总结癌症治疗中 SeNP 的所有最新关键靶向疗法以及众多功能化策略。我们还关注 SeNP 功能化方法和生物医学应用机制的最新进展，特别是在抗癌、抗炎和抗感染治疗方面。根据我们的观察，我们发现 SeNP 可能有助于抑制病毒流行，例如正在进行的 COVID-19 大流行，以补充其抗菌和抗寄生虫用途。 SeNP 是重要的纳米平台，具有许多临床转化所需的特性。© 2024。作者。

Selenium nanoparticles (SeNPs) are an appealing carrier for the targeted delivery. The selenium nanoparticles are gaining global attention because of the potential therapeutic applications in several diseases e.g., rheumatoid arthritis (RA), inflammatory bowel disease (IBD), asthma, liver, and various autoimmune disorders like psoriasis, cancer, diabetes, and a variety of infectious diseases. Despite the fact still there is no recent literature that summarises the therapeutic applications of SeNPs. There are some challenges that need to be addressed like finding targets for SeNPs in various diseases, and the various functionalization techniques utilized to increase SeNP's stability while facilitating wide drug-loaded SeNP distribution to tumor areas and preventing off-target impacts need to focus on understanding more about the therapeutic aspects for better understanding the science behind it. Keeping that in mind we have focused on this gap and try to summarize all recent key targeted therapies for SeNPs in cancer treatment and the numerous functionalization strategies. We have also focused on recent advancements in SeNP functionalization methodologies and mechanisms for biomedical applications, particularly in anticancer, anti-inflammatory, and anti-infection therapeutics. Based on our observation we found that SeNPs could potentially be useful in suppressing viral epidemics, like the ongoing COVID-19 pandemic, in complement to their antibacterial and antiparasitic uses. SeNPs are significant nanoplatforms with numerous desirable properties for clinical translation.© 2024. The Author(s).