本研究旨在探讨护士主导的多领域干预对头颈鳞状细胞癌 (HNSCC) 患者化疗引起的恶心和呕吐 (CINV) 的影响。 92 名接受顺铂化疗的 HNSCC 患者被分为干预组（n = 45）和对照组（n = 47）。对照组接受CINV的常规护理，包括根据医生的喜好给予止吐药、CINV控制教育和初级护士提供的饮食建议。干预组接受护士主导的循证多领域管理，包括护士主导的CINV危险因素评估、CINV预防和控制教育、遵循指南止吐、饮食策略和放松疗法。收集经历 CINV 的患者人数。 CINV 的严重程度根据不良事件通用术语标准 v3.0 进行分级。通过功能性生活指数-呕吐（FLIE）评估CINV对患者生活质量的影响。化疗后5天内，干预组恶心呕吐的发生率和严重程度显着低于对照组，干预组恶心呕吐维度得分显着高于对照组[63.00（50.00-63.00）比40.00（28.00-63.00）、63.00（63.00-63.00）比63.00（43.00-63.00） ）]，差异有统计学意义（P < 0.05）。护士主导的多域干预可以降低接受顺铂化疗的 HNSCC 患者 CINV 的发生率和严重程度，从而减少 CINV 对患者的影响' 生活质量。NCT05792228。版权所有 © 2024 Elsevier Ltd. 保留所有权利。

This study aimed to investigate the effect of a nurse-led multidomain intervention on chemotherapy induced nausea and vomiting (CINV) in patients with head and neck squamous cell carcinomas (HNSCC).Ninety-two HNSCC patients who received cisplatin-based chemotherapy were divided into intervention group (n = 45) and control group (n = 47). The control group received usual care of CINV, which consisted of administration of antiemetics according to physicians' preference, education about CINV control and dietary recommendations provided by primary nurses. The intervention group received nurse-led, evidence-based multidomain management, including nurse-led CINV risk factors assessment, education on prevention and control of CINV, antiemetics following guidelines, dietary strategies, and relaxation therapy. The number of patients who experienced CINV was collected. The severity of CINV was graded according to the Common Terminology Criteria for Adverse Events v3.0. The influence of CINV on patient's quality of life was assessed by the Functional Living Index-Emesis (FLIE).The incidence and the severity of nausea and vomiting in the intervention group were significantly lower than those in the control group within 5 days after chemotherapy, and the scores of the dimension of nausea and vomiting in the intervention group were significantly higher than those in the control group [63.00 (50.00-63.00) vs 40.00(28.00-63.00), 63.00(63.00-63.00) vs 63.00 (43.00-63.00)], the differences were statistically significant (P < 0.05).Nurse-led multidomain intervention can reduce the incidence and the severity of CINV in patients with HNSCC who were treated with cisplatin-based chemotherapy, and thus reduced the influence of CINV on patients' quality of life.NCT05792228.Copyright © 2024 Elsevier Ltd. All rights reserved.