癌症干细胞 (CSC) 已成为肿瘤发生、疾病进展和治疗耐药性的关键参与者。这篇综合综述深入探讨了不同癌症类型中 CSC 与起源细胞之间的复杂关系。对主题相关的综合综述我们探索了驱动正常细胞转化为 CSC 的潜在分子机制，以及源细胞对 CSC 特性、肿瘤发生和治疗反应的影响。此外，我们根据 CSC 独特的细胞起源特征讨论了针对 CSC 的潜在治疗干预措施。越来越多的证据表明，细胞起源（肿瘤起源的细胞类型）在决定 CSC 的特性方面发挥着至关重要的作用及其对肿瘤异质性的贡献。通过提供对 CSC 及其细胞起源之间复杂相互作用的重要见解，本文旨在增强我们对癌症生物学的理解，并为更有效和个性化的癌症治疗铺平道路。版权所有 © 2024 Bamodu, Chung 、皮萨尼奇和吴。

Cancer stem cells (CSCs) have emerged as pivotal players in tumorigenesis, disease progression, and resistance to therapies.This comprehensive review delves into the intricate relationship between CSCs and the cell-of-origin in diverse cancer types.Comprehensive review of thematically-relevant literature.We explore the underlying molecular mechanisms that drive the conversion of normal cells into CSCs and the impact of the cell-of-origin on CSC properties, tumor initiation, and therapeutic responses. Moreover, we discuss potential therapeutic interventions targeting CSCs based on their distinct cell-of-origin characteristics.Accruing evidence suggest that the cell-of-origin, the cell type from which the tumor originates, plays a crucial role in determining the properties of CSCs and their contribution to tumor heterogeneity.By providing critical insights into the complex interplay between CSCs and their cellular origins, this article aims to enhance our understanding of cancer biology and pave the way for more effective and personalized cancer treatments.Copyright © 2024 Bamodu, Chung, Pisanic and Wu.