脑膜瘤是非神经胶质肿瘤，是成人中最常见的原发性脑肿瘤。尽管脑膜瘤可以通过手术切除治愈，但非典型/间变性脑膜瘤的复发率很高，预后较差。因此，开发针对高级别脑膜瘤的新治疗方案至关重要。这篇综述重点介绍了脑膜瘤的当前组织学、普遍的遗传和分子变化，以及脑膜瘤中研究最广泛的信号通路和治疗方法。它还回顾了当前的临床研究和新型脑膜瘤治疗方法，包括免疫疗法、microRNA、癌症干细胞方法以及糖酵解途径内的靶向干预措施。通过检查脑膜瘤生物学的复杂情况并强调有希望的治疗途径，本综述为未来旨在改善这种常见颅内肿瘤实体的患者预后的研究工作开辟了道路。© 2024 作者。基因、染色体和癌症由 Wiley periodicals LLC 出版。

Meningiomas are non-glial tumors that are the most common primary brain tumors in adults. Although meningioma can possibly be cured with surgical excision, variations in atypical/anaplastic meningioma have a high recurrence rate and a poor prognosis. As a result, it is critical to develop novel therapeutic options for high-grade meningiomas. This review highlights the current histology of meningiomas, prevalent genetic and molecular changes, and the most extensively researched signaling pathways and therapies in meningiomas. It also reviews current clinical studies and novel meningioma treatments, including immunotherapy, microRNAs, cancer stem cell methods, and targeted interventions within the glycolysis pathway. Through the examination of the complex landscape of meningioma biology and the highlighting of promising therapeutic pathways, this review opens the way for future research efforts aimed at improving patient outcomes in this prevalent intracranial tumor entity.© 2024 The Authors. Genes, Chromosomes and Cancer published by Wiley Periodicals LLC.