黑色素瘤是儿童癌症幸存者中罕见的继发性恶性肿瘤。我们报道了一名 12 岁男孩的病例，他在完成肝母细胞瘤治疗 17 个月后出现恶性黑色素瘤并伴有全身转移。根据骨髓检查得出的诊断出人意料。该患者对免疫检查点抑制剂治疗没有反应，并在被诊断患有黑色素瘤后 6 周死亡。用于检查与癌症易感性相关的 103 个基因的全外显子组测序未发现任何种系变异。该案例研究提供了肝母细胞瘤治疗后儿童癌症幸存者中黑色素瘤的独特示例，但未发现任何将肝母细胞瘤和黑色素瘤联系起来的候选变异.© 2024 作者。 Wiley periodicals LLC 出版的癌症报告。

Melanoma is rare as a secondary malignant neoplasm among childhood cancer survivors.We report a case of a 12-year-old boy who developed malignant melanoma with systemic metastases 17 months after completing treatment for hepatoblastoma. The diagnosis was made unexpectedly based on a bone marrow examination. The patient did not respond to immune checkpoint inhibitor therapy and died 6 weeks after being diagnosed with melanoma. Whole-exome sequencing to examine 103 genes associated with cancer predisposition did not identify any germ-line variants.This case study provides a unique example of melanoma in a childhood cancer survivor following hepatoblastoma treatment but does not identify any candidate variant to link hepatoblastoma and melanoma.© 2024 The Author(s). Cancer Reports published by Wiley Periodicals LLC.